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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Cancer Chemother Pharmacol. 2014 Nov 6;75(1):67–75. doi: 10.1007/s00280-014-2618-2

Table 2.

Estimated pharmacodynamic model parameters

Structural Model Parameter Values Between subject variability (BSV, as %
CV, on diagonal) and correlation (as
Pearson r, off diagonal)
Parameter Designation Parameter Estimate
(RSE%)		 Lo kt kK
Baseline ALC Lo 0.954/μL
(10.8%)		 59%
Rate constant - transit of
lymphocytes through
proliferation and
differentiation		 kt 0.0441/hr
(7.39%)		 0.23 38.9%
Rate constant – increased
lymphocyte kill per unit of
F-ara-A concentration		 kK 30.2 /hr × (L/mg)
(41.7%)		 0.42 0.26 211%