Table 2.
Non-compartmental analysis of total and ultrafilterable (UF) plasma platinum concentration data and literature values.
| Study | Current | Current | Hennik 1987 [39] | Zamboni 2002 [40] | Kizu 1993[41] | Hardie 1991 [42] | Jacobs 2005 [43] | Urien 2004 [44] |
|---|---|---|---|---|---|---|---|---|
| Species | Shrew | Shrew | Mouse | Mouse | Rabbit | Dog | Rhesus Monkey | Human |
| Dose (mg/kg) | 20 | 20 | 10 | 10 | 3 | 4.5 | 2 | 0.67 |
| Route | IP | IP | IV | IV | IV | IV | 1 h IV | 0.5 h IV |
| Parameter | Total Pt (μg/ml) | UF Pt | UF Pt | UF Pt | UF Pt | UF Pt | UF Pt | UF Pt |
| Cmax (μg/mL) | 26.1 (13.2) | 20.3 (14.0) | 23.4 (2.2) | - | - | - | 2.43 (0.76) | - |
| Tmax (min) | 5 | 5 | - | - | - | - | - | - |
| t1/2 (h) | 83.2 | 0.195 | 0.10 | - | - | - | 0.331 (0.023) | 1.32 |
| AUC0-t (mg•h/L) | 200 | 6.28 | - | - | 4.04 (0.46) | - | 3.58 (1.18) | - |
| AUC0-inf (mg•h/L) | 437 | 6.33 | 4.38 | 3.9 | - | 1.77 | - | 0.737 |
| % AUC Extrapolated | 54 | 0.7 | - | - | - | - | - | - |
| Cl (L/h/kg) | 0.0298 | 2.05 | 2.28 | 1.67 | 0.743 | 1.65 (0.32) | 0.391 (0.130) | 0.588 |
| Vd (L/kg) | 3.57 | 577 | - | - | - | - | - | - |
Assuming typical human body weight of 70 kg. Conversions of parameter normalizations with kg and m2 based on Freireich [45].