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. Author manuscript; available in PMC: 2016 Jan 2.
Published in final edited form as: Circ Res. 2014 Oct 17;116(1):46–55. doi: 10.1161/CIRCRESAHA.116.305172

Figure 4. Lack of NOS1-derived NO underlies the atypical SR Ca2+ leak-temperature pattern in NOS1−/− cardiomyocytes.

Figure 4

(A) Dependence of SR Ca2+ leak on temperature in NOS1−/− cardiomyocytes in the absence or the presence of 1 μmol/L SNAP [at matched SR Ca2+ load ≈75 μmol/L] (* p < 0.05(-)SNAP vs. +SNAP-treated NOS1−/−, Two-way ANOVA). (B) Dependence of SR Ca2+ leak with temperature in WT cardiomyocytes in the absence or the presence of 100 μmol/L L-VNIO [at matched SR Ca2+ load ≈ 75 μmol/L] (* p < 0.05 (-)L-VNIO vs. +L-VNIO-treate WT, Two-way ANOVA).