Figure 1. TDP-1 maintains transcripts with potential dsRNA structure.

1. Scatter plot comparing the log₂ of transcript RPKMs (Reads Per Kilobase of transcript per Million mapped reads) between wild-type and tdp-1(ok803) poly(A)-selected RNA-seq experiments. Only transcripts significantly (corrected P < 0.05) increased (red) or decreased (blue) compared to wild-type are shown. Scatter plot represents significantly different genes calculated from two independent biological replicates of both wild-type and tdp-1(ok803) poly(A) RNA-seq prepared from L4 animals.
2. Percentage increased and decreased transcripts in tdp-1(ok803) poly(A) RNA-seq that have antisense overlap with another spliced gene or have intronic sequences (> 1 kb) that contain inverted repeats. *P < 1 × 10⁻⁴ (hypergeometric distribution); NS, not significant relative to control gene sets.