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. 2014 Nov 12;33(24):2947–2966. doi: 10.15252/embj.201488740

Figure 3. TDP-1 limits levels of A-I RNA editing.

Figure 3

  • A Fold change in % A-to-I editing in tdp-1(ok803) compared to wild-type RNA-seq is shown. For all regions, the average percent editing for each potentially edited nucleotide was calculated. Bars in graph represent the average percent editing across individual edited regions altered in tdp-1(ok803) (73 altered/154 analyzed). Genomic location of edited regions, actual change in percent editing and actual P-values are listed in Supplementary Table S4.
  • B, C Examples of hyper-edited intronic regions in tdp-1(ok803) mutant RNA-seq: intron 3 of ABC-transporter haf-6 (B) [ChrI: 1170900-1173858] and intron 9 of FOXO transcription factor daf-16 (C) [ChrI: 10774096-10774765]. Purple bars indicate annotated structural elements containing editing. Regions were divided into 10 equal windows and mean fraction edited for each window is plotted (y-axis). Connected points indicate editing in the same structural element. Percent editing in wild-type (blue), tdp-1(ok803) (red) and adr-2(gv42) (green) is shown. Scale bars (upper left, black), 100 bp.