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. 2014 Nov 28;33(24):2983–2996. doi: 10.15252/embj.201489050

Figure 6. Dual regulation of intestinal stem cells and their progeny by Escargot.

Figure 6

Schematic summary of the findings. Esg is required for ISC maintenance by inhibiting differentiation. In addition, Esg influences EB differentiation by inhibiting the expression of Amun, a Notch inhibitor, which indirectly leads to the positive modulation of Notch activity within EBs (dashed gray arrow).