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. Author manuscript; available in PMC: 2015 Jan 3.
Published in final edited form as: Expert Opin Investig Drugs. 2013 Dec 13;23(2):227–241. doi: 10.1517/13543784.2014.856879

Table 5.

GPI and MVD assay data for cyclic deltorphin (1 – 7) analogs and N-(ureidoethyl)amides of cyclic enkephalin analogs.

graphic file with name nihms647274u5.jpg
Compound number GPI MVD GPI/MVD Compound number Ring size GPI Relative potency MVD Relative potency GPI/MVD
IC50 (nM) IC50 (nM) IC50 ratio IC50 (nM) IC50 (nM) IC50 ratio
71 888 11.8 75/1 79 18 1.97 125 1.81 6.30 1.1/1
72 > 10,000 67.0 > 149/1 80 19 5.55 44.3 6.0 1.90 1/1.1
73 65.4 0.640 102/1 81 20 18.1 13.6 22.7 0.502 1/1.3
74 25.4 0.483 53/1 82 21 20.2 12.2 26.6 0.429 1/1.3
75 1020 2.73 374/1 83 17 11.3 21.8 14.1 0.809 1/1.2
76 159 0.814 195/1 84 18 3.36 73.2 11.6 0.983 1/3.5
77 460 106 4.3/1 85 19 6.87 35.8 16.5 0.691 1/2.4
78 > 10000 27.1 > 369/1 86 20 16.1 15.3 28.2 0.404 1/1.8
– – – – 35 – 246 1 11.4 1 21.6/1