Fig. 1.

Dystrophin at the neuromuscular junction. Neuromuscular junctions (NMJs) were fluorescently stained with an acetylcholine receptor binding neurotoxin (α-Bungarotoxin, BTX, green), and antibodies against dystropin (red). Dystrophin, a stabilizing membrane protein, is present at the NMJ in healthy (wild-type, WT) tissue, but is missing in mdx mice. NMJs from mdx muscle also show drastic morphological differences when compared with NMJs from WT mice. It has been suggested that the lack of dystrophin is indirectly involved with the fragmented appearance of acetylcholine receptors seen in mdx mice. Scale bar equals 10 µm