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. 2014 Dec 13;15:59. doi: 10.1186/s12865-014-0059-7

Figure 1.

Figure 1

Diagram of the Immunoglobulin Heavy chain and the regions that are sequenced. (A) Schematic representation of an immunoglobulin protein. The V, D and J part form the variable domain and the C part forms the constant domain of the protein. (B) IGH rearrangements are amplified using a forward primer in the V gene and a reverse primer in the J gene. The CDR3 region consisting of part of the V gene, the D gene and part of the J gene is indicated. The red arrows represent the region that is sequenced by 454.