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. 2014 Sep 26;40(11):3663–3673. doi: 10.1111/ejn.12727

Figure 4.

Figure 4

The selective 5-HT2C selective agonist (S)-2-(chloro-5-fluoro-indol-l-yl)-1-methylethylamine fumarate (RO 60-0175) reduced activity in INI and WT mice to a similar extent. (A) The inhibition of locomotion in response to treatment with RO 60-0175 is similar in INI and WT mice tested in the morning. Animals (n = 4–6) were injected with 5 mg/kg RO 60-0175 and their locomotor behaviour (total distance travelled) measured in an open field 30 min later. (B) Activity in running wheels was monitored from 19:00 h to 22:00 h and 22:00 h to 01:00 h in mice (n = 6) injected with 5 mg/kg RO 60-0175 at 18:30 h, 30 min before the onset of the dark period. The graphs show the hourly wheel revolutions on the day prior to any intervention (basal) and on the day of saline or agonist injection. Values are mean + SEM; *P < 0.05.