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. Author manuscript; available in PMC: 2015 Jan 28.
Published in final edited form as: Cancer Lett. 2014 Oct 18;356(2 0 0):656–668. doi: 10.1016/j.canlet.2014.10.015

Fig. 7.

Fig. 7

Panobinostat enhances the antitumor activity of MK-1775 in a BxPC-3 xenograft model. A, body weights were measured every 3–4 days. B, tumor volumes were calculated according to the following formula: m12 × m2× 0.5236 (m1: short diameter; m2: long diameter). C–E, tumor specimens were fixed in 10% formalin, embedded in paraffin, and cut into 4 μM-thick slides for H&E (C) and PCNA staining (D). The proliferation index was calculated as proliferation index = PCNA positive cells/observed cells × 100% and graphed as means ± standard errors (E). F, apoptosis was measured using the TUNEL assay in the tumor specimens. G, apoptosis index was calculated as TUNEL-positive cells/observed cells × 100% and graphed as means ± standard errors. *** indicates p < 0.0005.