Skip to main content
. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Best Pract Res Clin Obstet Gynaecol. 2014 Aug 19;29(1):110–122. doi: 10.1016/j.bpobgyn.2014.04.019

Table 2.

Randomized Trials of Lifestyle Interventions to Reduce Risk of Type 2 Diabetes among Women with Gestational Diabetes Mellitus (GDM); Findings.

Author (year) Name Impact on Type 2
Diabetes
Impact on Biomarkers
of Insulin Resistance
Impact on Weight Impact on PA Impact on Diet Impact on
Breastfeeding
Cheung et al.; 2011 NA NA BMI (kg/m2): 28 (95% CI:
23.9, 34.3) vs. 25.5 (95%
CI: 22.5, 28.7), p=0.14
Steps (% achieving goal):
30.8 vs. 17.6 p=0.34;
PA (% achieving goal):
70.0 vs. 57.9, p=0.51
NA
Ferrara et al.; 2011 DEBI (Diet, Exercise and
Breastfeeding
Intervention)
NA NA Weight (% achieving
goal): 37.5% vs. 21.4%,
p=0.07
PA (difference in mean
change in min/wk.):
25.3, p=0.91
Fat (% difference in
mean change) −3.6,
p=0.002
Breastfeeding
(difference in %
partially or exclusively
breastfeeding):
15%,
p=0.09
Hu et al.; 2012 Tianjin
Gestational
Diabetes
Mellitus
Prevention
Program
(TGDMPP)
NA FG (change in mmol/l): −0.09±.52 vs. −0.09±0.6,
p=0.97; Insulin (change
in pmol/l): −11.8±27.4
vs. −3.2±31.2, p=0.004
Weight change: −
1.4±3.44 kg vs −
0.21±3.52 kg (0.3%),
p=0.001;
BMI change: −0.50±1.41
kg/m2 vs. −0.09±1.37
kg/m2, p=0.004
LTPA (% increased):
59.4% vs. 26.9%,
p<0.001
Fat (% decrease): 77.1
vs. 68.9, p=0.064;
Fiber (% increase) 59.5
vs. 47.4, p=0.012
NA
Kim et al.; 2012 NA FG (change in mmol/l): −
0.046 vs. 0.038, p=0.65; 2 hr. glucose on 75g
OGTT (change in
mmol/l): −0.48 vs. −0.42,
p=0.91
Weight (change in kg): −
0.14 kg vs. −1.5 kg,
p=0.13
PA (% moderate-intensity): 58 vs. 47,
p=0.51
NA NA
McIntyre et al.; 2012 NA FG (change in mmol/L):
0.25+.56 vs. 0.12+0.42,
NS; Insulin (change in
µU/mL): 1.49+4.23 vs.
0.06+3.89, NS
Change in weight (kg):
0.97+3.7 vs. 0.22+4.2 NS
PA (median [range]
increase in planned PA
mins./wk.): 60 (0–540)
vs. 0 (0–580); p=0.234;
walking: NS
NA NA
Ratner et al.; 2008 Diabetes
Prevention
Project (DPP)
Diabetes: 53% risk
reduction vs.
placebo, p=0.002
NA Weight (change in kg): −
5.13±0.43 vs. approx. 0
in placebo at 6 mos.; − 1.6±0.80 vs. approx. 0 in
placebo at 3 yrs.
PA (change in h/wk.): 1.5
h/wk. vs. NA in yr. 1;
<0.5 vs NA in yr. 3.
NA NA
Reinhardt et al.; 2012 NA NA BMI (difference in change in kg/m2): −1.5
(95% CI: −2.8, −0.1);
Weight (difference in
change in kg): −4.0 (95%
CI: −7.6, −0.5)
LTPA (change in
min/day): 11 (95% CI: 1,
22)
Total fat (change in
g/day): −19 (95%CI: −37, − 1); GL
(unit change) −26 (95%
CI −48, −4)
NA
Shyam et al.; 2013 NA Glucose: 2hr post 75g
OGTT (median mmol/l,
IQR): −0.2 (2.8) vs. 0.8
(2.0), p=0.025; Insulin
(<2 µU/L): 61.5% vs.
52.6%, p=0.228
Weight (% achieving
goal): 33% vs.
8%,
p=0.01
PA (median METmin/
wk., IQR): 933
(1403) vs. 965 (857),
p=0.908
Fat (g): 58±18 vs.
53±16, p=0.695 for
difference in change;
Fiber (g): 17±4 vs. 13±4,
p=0.02 for difference in
change; GI:
57±5 vs. 64±6, p=0.033
for difference in change
Wein et al.; 1999 Diabetes (annual
IR):
6.1% vs. 7.3%
(IRR=0.83, 95% CI:
0.47, 1.48)
NA NA NA NA

RCT = randomized clinical trial; FU = follow-up; GDM= gestational diabetes mellitus; IGT= impaired glucose tolerance; PA=physical activity; FG=fasting glucose; GI = glycemic index; PA = physical activity,