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Ovarian cancer cell expresses cdr 2 antigen that triggers immune response against malignancy. The same cdr2 antigen is a intracellular protein in Purkinje cell in cerebellum. As a result, cytotoxic T lymphocytes (CTL) cross-react against nervous tissue. This mechanism represents the prevailing view on the pathogenesis of paraneoplastic cerebellar degeneration (PCD) related to ovarian cancer. The hallmarks of immune reaction, however, are not detected in all patients
