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. 2014 Jun 26;141(1):99–108. doi: 10.1007/s00432-014-1745-9

Fig. 2.

Fig. 2

NMDA receptor (NMDAR) is expressed on the surface of ovarian teratoma cells. As a result of immune reaction, anti-NNMAR antibodies are produced. The same receptor is present at the dendrites of neurons in many region of central nervous system. Anti-NMDAR antibodies enter nervous tissue through the vasculature and react against the target protein. Consequently, neural signaling mediated by NMDA receptor is considerably disturbed leading to both psychiatric and neurologic symptoms