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Population pharmacokinetic model parameters for patients receiving short and long daunorubicin infusions
| Parameter | Population mean |
Interindividual variability |
|---|---|---|
| CL—Daunorubicin (L/h/m2) | 116 (±14 %) | 63.6 % ± 24.1 % |
| V1—Daunorubicin (L/m2) | 68.1 (±24 %) | 151 % ± 23 % |
| V2—Daunorubicin (L/m2) | 128 (±25 %) | 80.1 % ± 26 % |
| Q—Daunorubicin (L/hr/m2) | 312 (±15 %) | 99.0 % ± 31 % |
| CLm/F—Daunorubicinol (L/h/m2) | 26.8 (±5.6 %) | 63.6 % ± 22.6 % |
| Vm/F—Daunorubicinol (L/m2) | 232 (±10 %) | 108.6 % ± 27.9 % |
