Skip to main content
. Author manuscript; available in PMC: 2015 Jan 4.
Published in final edited form as: Cancer Chemother Pharmacol. 2014 Aug 14;74(4):831–838. doi: 10.1007/s00280-014-2535-4

Table 4.

Effect of percentage body fat on daunorubicin and daunorubicinol pharmacokinetic parameters

Parameter (units) FAT % <30 (median ± SD)
N = 33		 FAT % >30 (median ± SD)
N = 15		 p value
CL—Daunorubicin (L/h/m2) 123 ± 83.6 112 ± 54.3 0.39
V1—Daunorubicin (L/m2) 62.7 ± 180 37.5 ± 142 0.13
V2—Daunorubicin (L/m2) 309 ± 227 261 ± 178 0.14
Q—Daunorubicin (L/h/m2) 149 ± 130 106 ± 73.1 0.053
CLm/F—Daunorubicinol (L/h/m2) 36.0 ± 26.1 30.6 ± 8.8 0.23
Vm/F—Daunorubicinol (L/m2) 387 ± 211 424 ± 174 0.18