Table 1.
Demographics, pathology and genetics of case material
| HpScl n=35 |
Not HpScl n=634 |
P-value | |
|---|---|---|---|
| Demographic characteristics | |||
| Male | 17 (49%) | 387 (61%) | 0.197 |
| Age at death, years | 81 (78, 85) | 78 (73, 84) | 0.010 |
| Post-mortem findings | |||
| Brain weight, grams | 1000 (880, 1140) | 1140 (1040, 1260) | <0.001 |
| Braak NFT stage | VI (III, VI) | IV (III, V) | <0.001 |
| Thal amyloid-β phase | 5 (4, 5) | 4 (3, 5) | 0.003 |
| Lewy body subtype | |||
| Diffuse | 21 (60%) | 359 (57%) | 0.828 |
| Limbic | 14 (40%) | 275 (43%) | |
| TDP-43 positivity | 35 (100%) | 133 (21%) | <0.001 |
| Type A | 35/35 (100%) | 66/133 (50%) | <0.001 |
| Type B/NFT | 0/35 (0%) | 43/133 (32%) | |
| Unclassified | 0/35 (0%) | 24/133 (18%) | |
| Genetic findings | |||
| TMEM106B, C allele carriers | 14/32 (44%) | 370/527 (70%) | 0.003 |
| GRN, T allele carriers | 21/32 (66%) | 277/527 (53%) | 0.209 |
| APOE, ε4 allele carriers | 21/32 (66%) | 293/538 (54%) | 0.293 |
All data is displayed as median (25th, 75th range), unless otherwise noted. TMEM106B rs1990622 C allele, GRN rs5848 T allele, and APOE ε4 allele carriers are displayed as number genotyped out of available cases.