Table 3.
Semi-quantitative assessment of TDP-43 pathology
| HpScl | Not HpScl | ||||||
|---|---|---|---|---|---|---|---|
| Type A n=35 |
Type A n=19 |
Type B/NFT n=13 |
P-value | ||||
| TDP-43 score |
Positivity | TDP-43 score |
Positivity | TDP-43 score |
Positivity | ||
| Neuronal cytoplasmic lesions | |||||||
| Dentate fascia | 2 (1, 3) | 35/35 (100%) |
1 (1, 1)** | 18/19 (95%) |
0.5 (0, 0.5)** | 9/13 (70%) |
<0.001 |
| CA1 | 0.5 (0.5, 1) | 30/35 (86%) |
0.5 (0.5, 1) | 15/19 (79%) |
1 (0.25, 1) | 10/13 (77%) |
0.619 |
| Subiculum | 1 (1, 2) | 35/35 (100%) |
1 (1, 2) | 16/19 (84%) |
1 (1, 2) | 13/13 (100%) |
0.550 |
| Parahippocampal gyrus | 2 (1, 3) | 35/35 (100%) |
2 (1, 3) | 17/19 (89%) |
1 (1, 2)* | 13/13 (100%) |
0.024 |
| Inferior temporal gyrus | 1 (0, 2) | 20/27 (74%) |
0.5 (0, 2) | 9/15 (60%) |
0 (0, 0.625)* | 3/10 (30%) |
0.047 |
| Amygdala | 2 (2, 3) | 33/33 (100%) |
3 (1, 3) | 19/19 (100%) |
3 (1.5, 3) | 13/13 (100%) |
0.930 |
| Putamen | 0 (0, 5) | 9/33 (27%) |
0 (0, 0)* | 0/19 (0%) |
0 (0, 0)* | 0/13 (0%) |
0.007 |
| Mid-frontal gyrus | 0 (0, 0) | 6/35 (17%) |
0 (0, 0) | 3/19 (16%) |
0 (0, 0) | 0/13 (0%) |
0.293 |
| Substantia nigra | 0 (0, 0) | 4/34 (12%) |
0 (0, 0) | 1/19 (5%) |
0 (0, 0) | 0/13 (0%) |
0.362 |
| Hypoglossal nucleus | 0 (0, 0) | 0/26 (0%) |
0 (0, 0) | 1/17 (6%) |
0 (0, 0) | 0/12 (0%) |
0.327 |
| Neuritic lesions | |||||||
| Dentate fascia | 0.5 (0, 0.5) | 24/35 (69%) |
0 (0, 0.5)* | 6/19 (32%) |
0 (0, 0)** | 1/13 (8%) |
<0.001 |
| CA1 | 2 (1, 3) | 35/35 (100%) |
1 (0.5, 2) | 19/19 (100%) |
0 (0, 0)** | 2/13 (15%) |
<0.001 |
| Subiculum | 1 (0.5, 2) | 35/35 (100%) |
1 (1, 2) | 18/19 (95%) |
0.5 (0, 0.5)** | 7/13 (54%) |
<0.001 |
| Parahippocampal gyrus | 2 (1, 3) | 35/35 (100%) |
1 (0.5, 3) | 17/19 (89%) |
0 (0, 0.75)** | 5/13 (40%) |
<0.001 |
| Inferior temporal gyrus | 0.5 (0, 2) | 20/27 (74%) |
0.5 (0, 1) | 8/18 (53%) |
0 (0, 0)** | 1/10 (10%) |
0.004 |
| Amygdala | 1 (1, 2) | 32/33 (97%) |
2 (0.5, 2) | 17/19 (89%) |
1 (0.25, 1)* | 10/13 (77%) |
0.020 |
| Putamen | 0 (0, 0.25) | 8/33 (24%) |
0 (0, 0)* | 0/19 (0%) |
0 (0, 0) | 0/13 (0%) |
0.013 |
| Mid-frontal gyrus | 0 (0, 0) | 6/35 (17%) |
0 (0, 0) | 3/19 (16%) |
0 (0, 0) | 0/13 (0%) |
0.290 |
| Substantia nigra | 0 (0, 0.5) | 15/34 (44%) |
0 (0, 0) | 4/19 (21%) |
0 (0, 0)* | 0/13 (0%) |
0.008 |
| Hypoglossal nucleus | 0 (0, 0) | 0/26 (0%) |
0 (0, 0) | 0/17 (0%) |
0 (0, 0) | 0/12 (0%) |
1.000 |
|
Neuronal nuclear inclusions |
n/a | 31/35 (89%) |
n/a | 11/19 (58%)* |
n/a | 1/13 (8%)** |
<0.001 |
TDP-43-positive cytoplasmic and neuritic lesions were scored separately using a 5 point grading scale (0= none, 0.5= rare, 1 = mild, 2=moderate, 3=severe). TDP-43 score shows median (25th, 75th range) in each brain region. Positivity is number TDP-43-positive out of available cases in each brain region. Abbreviations: n/a., not assessed.
*
p<0.05
**
P<0.001 vs. HpScl-Type A.