. Author manuscript; available in PMC: 2016 Jan 1.

Published in final edited form as: Acta Neuropathol. 2014 Nov 4;129(1):53–64. doi: 10.1007/s00401-014-1358-z

Table 4.

Comparison of demographics and genetics by subtype of TDP-43 pathology

	HpScl	Not HpScl		P-value

	Type A n=35	Type A n=66	Type B/NFT n=43
Male	17 (49%)	32 (48%)	19 (44%)	0.893
Age at death, years	81 (78, 85)	82 (77, 86)	82 (77, 86)	0.953
TMEM106B, C allele carriers	14/32 (44%)	42/55 (76%)^*	25/34 (74%)^*	0.005
GRN, T allele carriers	21/32 (66%)	32/55 (58%)	19/34 (56%)	0.697
APOE, ε4 allele carriers	21/32 (66%)	42/58 (72%)	21/36 (58%)	0.367

Age at death is displayed as median (25th, 75th range). TMEM106B C allele, GRN T allele, and APOE ε4 allele carriers are displayed as number genotyped out of available cases.

p<0.05 vs. HpScl-Type A.