Table 1.
Demographic Characteristics of the Patients; Tumor Type; Biochemical Results
| Patient | Sex | Race | Age at Diagnosis | Tumors | TSS | Adrenalectomy |
|---|---|---|---|---|---|---|
| 1 | F | African-American | 13.9 | Metastatic hepatic neuroendocrine tumor (12 cm) | No | No |
| 2 | M | White | 10.5 | Metastatic pancreatic NET (primary tumors were 2 lobular masses above the pancreatic tail and next to the spleen, measuring 2.4 × 2.3 cm, 3.5 × 2 cm) | No | Yes |
| 3 | M | African-American | 13.6 | Poorly differentiated thymic carcinoid | Yes | No |
| 4 | F | White | 11.2 | Metastatic pancreatic neurorendocrine tumor (primary tumor at distal pancreatic tail measuring 1.4 cm) | Yes | Yes |
| 5 | F | White | 13.6 | Bronchogenic carcinoid tumor of right lower pulmonary lobe (1.3 cm) | No | No |
| 6 | M | White | 21.3 | Atypical thymic carcinoid (6 mm) | Yes | Yes |
| 7 | M | White | 1.8 | Pancreatoblastoma (7 cm) | No | No |
| Patient | Midnight Cortisol (ug/dL) | Morning Cortisol (ug/dL) | Midnight ACTH (pg/mL) | Morning ACTH (pg/mL) | Pre-op ACTH (pg/mL) | Post-op ACTH (pg/mL) | Pre-op UFC (ug/24 h) | Pre-op UFC (× NL) | Post-op UFC (ug/24 h) | Post-op UFC (× NL) | Pre-op Plasma CRH (pg/mL) | Post-op Plasma CRH (pg/mL) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NA | NA | NA | NA | NA | NA | 793.00 | 14.16 | NA | NA | 2.4 | NA |
| 2 | 9.5 | 13 | 40.7 | 44.4 | 79.70 | 8.5 | 64.00 | 1.73 | 0.7 | 0.27 | 248 | 2.7 |
| 3 | 29.4 | 30.4 | 141.5 | 222.5 | 217.00 | 27.1 | 939.00 | 16.77 | 334 | 5.96 | 2.8 | NA |
| 4 | 23.2 | 26.1 | 51 | 41.9 | 47.00 | 46.7 | 834.00 | 22.54 | 1.9 | 0.73 | 2.6 | NA |
| 5 | 23.8 | 32 | 65.2 | 66.8 | 103.00 | 5 | 817.50 | 14.60 | 18.8 | 1 | 2.7 | NA |
| 6 | 17.5 | 22.5 | 89.4 | 121 | 230.00 | 86.1 | 1013.50 | 22.52 | NA | NA | 3.3 | 2.4 |
| 7 | NA | NA | NA | NA | 101.00 | NA | NA | NA | NA | NA | 4.4 | NA |
| Patient | IPS/P Baseline ACTH Ratio | IPS/P Post- CRH ACTH Ratio | Baseline Cortisol (ug/dL) | Post-CRH Cortisol (ug/dL) | % Cortisol Change | Baseline ACTH (pg/mL) | Post-CRH ACTH (pg/mL) | % ACTH Change | Baseline Serum Cortisol (ug/dL) | Post-dexa Serum Cortisol (ug/dL) | Serum cortisol Change (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NA | NA | 59.8 | 58.6 | −1.92 | 57.5 | 59.8 | 4.09 | NA | NA | NA |
| 2 | 1.17 | 1.45 | 21.3 | 23.1 | 8.45 | 65.1 | 61.4 | −5.61 | 11.1 | 3.8 | −65.77 |
| 3 | 1.23 | 1.02 | 29.8 | 31.4 | 5.20 | 246.0 | 212.5 | −13.62 | 28.9 | 24.3 | −15.92 |
| 4 | 7.62 | 10.87 | 28.5 | 32.7 | 14.56 | 45.7 | 54.5 | 19.39 | NA | NA | NA |
| 5 | 1.04 | 1.40 | 18.3 | 18.7 | 2.19 | 57.3 | 68.85 | 20.26 | 20.6 | 6 | −70.87 |
| 6 | 1.46 | 1.52 | 53.8 | 61.1 | 13.67 | 119.5 | 213.5 | 78.66 | 18.1 | 15 | −17.13 |
| 7 | NA | NA | 135.9 | NA | NA | NA | NA | NA | NA | NA | NA |