Table 1.

The likely percentage of the population eligible for screening and of the cases potentially detectable by screening, considering age-based and personalized screening for breast and prostate cancers with increasing numbers of known susceptibility variants

Screening strategy	Population eligible for screening (%)	Cases potentially detectable by screening (%)
	Age 35–79 years; n = 13 126 890	Age 35–79 years; n = 30 936
Breast cancer
Age-based screening (47–73 years)	57	72
Personalized screening (age 35–79 years and 10-year absolute risk ≥2.5%)
Currently known variants (variance = 0.28)	43	71
Variants explaining 50% of familial risk (variance = 0.72)	35	72
Variants explaining 100% of familial risk (variance = 1.44)	28	76
	Age 45–79 years; n = 8 655 126a	Age 45–79 years; n = 22 836a
Prostate cancer
Age-based screening (55–79 years)	63	96
Personalized screening (age 45–79 years and 10-year absolute risk ≥2.0%)
Currently known variants (variance = 0.44)	51	92
Variants explaining 50% of familial risk (variance = 0.79)	45	91
Variants explaining 100% of familial risk (variance = 1.58)	34	89

^aEstimates are based on the population and cancer registrations in 2002–2006 in England.