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. 2013 Nov 11;26(12):679–688. doi: 10.1002/jmr.2313

Figure 3.

Figure 3

Structural and functional modulation of ACC2. (A) AFM nanoscale imaging was obtained for ACC2 alone, ACC2 + citrate, ACC2 + citrate + Spot14/Mig12 αβ, and ACC2 + citrate + Spot14/Mig12 (αβ)6 after 20 min incubation at 37 °C. Citrate induced ACC2 polymerization producing microfilaments. Spot14/Mig12 αβ and (αβ)6 suppressed complete and partial ACC2 polymerization, respectively. Height image of the AFM data is shown with a 15-nm color height scale. (B) Activity of recombinant ACC2 was measured in the presence of different Spot14/Mig12 concentrations. Cit, citrate.