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. 2014 Apr 9;54(9):995–1005. doi: 10.1002/jcph.302

Table 4.

Median Predicted ΔΔQTcF Interval at Selected Time Points After Doubling the Individual Moxifloxacin Concentrations at Each Time Point in the Original Dataset (N = 1000 Simulated Studies)

Time (hours) Median moxifloxacin concentration (ng mL–1) Lower bound 90% CI Median ΔΔQTcF (milliseconds) Upper bound 90% CI
0 0 –1.7 –0.02 1.7
1 1072 1.2 3.4 6.1
2 2430 4.4 7.1 9.7
3 2730 5.5 8.2 11.1
4 2560 5.3 7.9 10.6
5 2340 4.7 7.3 9.7
6 2240 4.2 6.7 9.2