Table 1. Familial correlations of sIL-6R level.
| Complete pairs | Correlations, no correction for SNP effectsd | Correlations, correction for rs2228145e | |||
|---|---|---|---|---|---|
|
| |||||
| N | r | 95% CI | r | 95% CI | |
| Monozygotic twins | |||||
| MZ male twins | 208 | 0.80 | (0.7607 - 0.8388) | 0.56 | (0.4530 - 0.6416) |
| MZ female twins | 520 | 0.68 | (0.6421 - 0.7207) | 0.35 | (0.2852 - 0.4248) |
| Male siblings | |||||
| DZ male twins | 93 | 0.40 | (0.2083 - 0.5566) | 0.24 | (0.0258 - 0.4324) |
| Male sibsa | 126 | 0.24 | (0.0882 - 0.3859) | 0.27 | (0.1033 - 0.4129) |
| Female siblings | |||||
| DZ female twins | 216 | 0.37 | (0.2627 - 0.4688) | 0.25 | (0.1445 - 0.3612) |
| Female sibsb | 313 | 0.29 | (0.1784 - 0.4018) | 0.12 | (0.0116 - 0.2250) |
| Opposite-sex siblings | |||||
| DZ opposite-sex twins | 224 | 0.31 | (0.1884 - 0.4282) | 0.15 | (0.0191 - 0.2782) |
| Opposite-sex sibsc | 337 | 0.42 | (0.3276 - 0.5121) | 0.20 | (0.0748 - 0.3250) |
| Parent-offspring | |||||
| Mother-daughter | 342 | 0.33 | (0.2543 - 0.4076) | 0.18 | (0.0975 - 0.2581) |
| Mother-son | 204 | 0.43 | (0.3434 - 0.5174) | 0.29 | (0.1700 - 0.3969) |
| Father-son | 171 | 0.36 | (0.2626 - 0.4447) | 0.20 | (0.0708 - 0.3190) |
| Father-daughter | 314 | 0.31 | (0.2311 - 0.3915) | 0.18 | (0.0928 - 0.2748) |
| Spouses | |||||
| Mother-Father | 374 | 0.11 | (0.0269 - 0.2075) | 0.24 | (0.1563 - 0.3317) |
a
Non-twin brother-brother pairs and pairs of brother-male twin
b
Sister-sister and Sister-female twin
c
Sister-brother, brother-female twin and sister-male twin
d
Correlation from a saturated model with covariates age and sex
e
Correlation from a saturated model with covariates age, sex and rs2228145 genotype. CI =Confidence interval. Note that the correlations of sIL-6R levels adjusted for the effect of rs2228145 provide information about the proportions of residual variance due to genetic and environmental effects. The proportion of the total phenotypic variance that is due to genetic effects beyond rs2228145 is reflected in the difference between the correlations with and without adjustment for rs2228145 genotype. MZ= monozygotic, DZ= dizygotic.