Table 4.

Visit schedule, arm 2

	Screening	Week 0	Week 24	Week 28	Week 32	Week 36	Week 40	Week 44	Week 48 (final visit)
Visit number	V1	V2	V3	V4	V5	V6	V7	V8	V9
Consent form	X
Medical history	X
Dietary survey		X
Physical exam and vital signs	X	X	X	X	X	X	X	X	X
Adverse events		X	X	X	X	X	X	X	X
Hematology	X	X	X	X	X	X	X	X	X
Chemistry	X	X	X	X	X	X	X	X	X
Pregnancy test (women only)	X		X
Hepatitis B and C tests	X
ART review	X
Syphilis test1	X		X						X
T-cell activation and inflammatory markers		X	X						X
HIV viral load2	X		X			X			X
Levels of tryptophan, niacin and its derivatives		X	X		X		X		X
ER niacin admin3				X	X	X	X	X	X
Bays-Ballantyne questionnaire				X	X	X	X	X	X
WHOQOL-HIV BREF, CES-D, POMS, HVLT-R™, and CANTAB™ tests4		X	X						X
SMAQ5		X	X			X			X

¹If syphilis test is positive at screening, participants will be retested at weeks 24 and 48.

²HIV viral load testing will be performed as indicated by treating physician.

³Participants will start ER niacin administration after their week 24 visit.

⁴Neurocognitive assessments are optional; WHOQOL-HIV BREF, World Health Organization quality of life instrument in patients with HIV infection-brief; CES-D, Center for Epidemiologic Studies Depression Scale; POMS, Profile of Mood State; HVLT-R™, Hopkins Verbal Learning Test Revised; CANTAB, Cambridge Neuropsychological Test Automated Battery.

⁵SMAQ, Simple Medication Adherence Questionnaire.