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. 2014 Oct 21;12:199. doi: 10.1186/1479-5876-12-199

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© McNeil et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Comparison of urinary sMet levels among BCa patients and controls. A. Box and whisker plot of urine sMet/creatinine values (ng sMet/mg creatinine) for control patients with no evidence of BCa (n = 83) and patients with pathology proven BCa (n = 183). Red asterisk indicates significant difference in median value from control (Mann–Whitney test with Bonferroni multiple test correction). B. Box and whisker plots of urine sMet/creatinine values (ng sMet/mg creatinine) for control patients with no evidence of BCa and patients with BCa subdivided by pathologic stage. N for each group are listed in Table 1. Red asterisks indicate significant difference in median value from control; black asterisks indicate significant differences among medians as indicated by brackets (Mann–Whitney test with Bonferroni multiple test correction). C. Box and whisker plot of urine sMet/creatinine values (ng sMet/mg creatinine) for control patients with no evidence of BCa (n = 83), patients with NMIBCa (n = 141) or with MIBCa (n = 42). Red asterisks indicate significant difference in median value from control; black asterisk indicates significant differences among medians as indicated by brackets (Mann–Whitney test with Bonferroni multiple test correction). D. ROC curve of urine sMet/creatinine values (ng sMet/mg creatinine) for control patients with no evidence of BCa (n = 83) and patients with pathology proven BCa (n = 183). E. ROC curve of urine sMet/creatinine values (ng sMet/mg creatinine) for patients with NMIBCa (n = 141) or with MIBCa (n = 42). Criterion values balancing sensitivity and specificity are indicated by the gray lines tangent to the ROC curves.