Table 4.

Variables assessed at specific times (S: screening, M: month)

Variables	Measures	S	M0	M3	M6	M9	M12
Primary outcome
Global cognition	ADAS-Cog		x	x	x	x	x
Secondary outcome
Brain volumes
Hippocampal volume	MRI		x		x		x
Brain volume	MRI		x		x		x
Ventricle volume	MRI		x		x		x
Other outcomes
Discreet cognitive domains
Attention	Digit Span (Wechsler)		x	x	x	x	x
Processing speed	Digit Symbol (Wechsler)		x	x	x	x	x
	TMT Part A
Executive function	TMT Part B		x	x	x	x	x
	EXIT-25
	BDS Executive Clock Drawing test
Memory	Logical Memory Story A and B		x	x	x	x	x
	Immediate Recall
	Delayed Recall
Language	Verbal Fluency		x	x	x	x	x
	Animal
	Vegetable
	Naming
	Boston Naming Test
Exercise adherence	Percent	Every exercise session
Aerobic fitness	Symptom-limited peak cycle-ergometer test,	x		x	x	x	x
	Shuttle-walk test, 6-minute walk test		x	x	x	x	x
Physical function	SPPB, DAD		x	x	x	x	x
BPSD	NPI-Q, AMS, CSDD		x	x	x	x	x
Medical changes	Medical diagnoses, falls, medications, and health care service use	Monthly
Covariates
AD stage	CDR, MMSE	x
Demographics	Age, education, gender, race	x
Premorbid intellect	WTAR		x
Unsupervised physical activity	PASE, actigraph	Monthly

Abbreviations: AD Alzheimer’s disease, ADAS-Cog Alzheimer’s Disease Assessment Scale-Cognition, AMS Alzheimer’s Mood Scale, BDS Behavioral Dyscontrol Scale, BPSD behavioral and psychological symptoms of dementia, CDR Clinical Dementia Rating, CSDD Cornell Scale for Depression in Dementia, DAD Disability in Alzheimer’s Disease scale, EXIT-25 Executive Interview-25, MRI magnetic resonance imaging, MMSE Mini-Mental State Examination, NPI-Q Neuropsychiatric Inventory-Caregiver, PASE Physical Activity Scale for the Elderly, SPPB Short Physical Performance Battery, TMT Trail Making Test, WTAR Wechsler Test of Adult Reading.