Table 1.
Common proteins identified in exosomes isolated from fresh plasma and after freeze/thawing cycles
| Protein ID | Symbol | Entrez gene name | Location | Type(s) |
|---|---|---|---|---|
| A2MG_HUMAN | A2M | alpha-2-macroglobulin | Extracellular Space | transporter |
| A2ML1_HUMAN | A2ML1 | alpha-2-macroglobulin-like 1 | Cytoplasm | other |
| ACACA_HUMAN | ACACA | acetyl-CoA carboxylase alpha | Cytoplasm | enzyme |
| ACTN3_HUMAN | ACTN3 | actinin, alpha 3 | Plasma Membrane | other |
| ADAL_HUMAN | ADAL | adenosine deaminase-like | Cytoplasm | enzyme |
| ATS16_HUMAN | ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | Extracellular Space | other |
| ATS9_HUMAN | ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | Extracellular Space | peptidase |
| DSRAD_HUMAN | ADAR | adenosine deaminase, RNA-specific | Nucleus | enzyme |
| ADCY7_HUMAN | ADCY7 | adenylate cyclase 7 | Plasma Membrane | enzyme |
| KFA_HUMAN | AFMID | arylformamidase | Nucleus | enzyme |
| ANGT_HUMAN | AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Extracellular Space | growth factor |
| ALBU_HUMAN | ALB | albumin | Extracellular Space | transporter |
| AMZ1_HUMAN | AMZ1 | archaelysin family metallopeptidase 1 | Other | peptidase |
| ANK2_HUMAN | ANK2 | ankyrin 2, neuronal | Plasma Membrane | other |
| ANKAR_HUMAN | ANKAR | ankyrin and armadillo repeat containing | Nucleus | transcription regulator |
| AKD1B_HUMAN | ANKDD1B | ankyrin repeat and death domain containing 1B | Other | other |
| ANKL1_HUMAN | ANKLE1 | ankyrin repeat and LEM domain containing 1 | Other | other |
| ANR12_HUMAN | ANKRD12 | ankyrin repeat domain 12 | Nucleus | other |
| ANR26_HUMAN | ANKRD26 | ankyrin repeat domain 26 | Nucleus | transcription regulator |
| ANKUB_HUMAN | ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | Other | other |
| APOA1_HUMAN | APOA1 | apolipoprotein A-I | Extracellular Space | transporter |
| APOB_HUMAN | APOB | apolipoprotein B | Extracellular Space | transporter |
| APOL1_HUMAN | APOL1 | apolipoprotein L, 1 | Extracellular Space | transporter |
| APOP1_HUMAN | APOPT1 | apoptogenic 1, mitochondrial | Cytoplasm | other |
| DP13B_HUMAN | APPL2 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 | Cytoplasm | other |
| RHG15_HUMAN | ARHGAP15 | Rho GTPase activating protein 15 | Cytoplasm | other |
| RHG08_HUMAN | ARHGAP8/PRR5-ARHGAP8 | Rho GTPase activating protein 8 | Cytoplasm | other |
| ARHGB_HUMAN | ARHGEF11 | Rho guanine nucleotide exchange factor (GEF) 11 | Cytoplasm | other |
| ASPM_HUMAN | ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | Nucleus | other |
| ATG2B_HUMAN | ATG2B | autophagy related 2B | Other | other |
| AT2A3_HUMAN | ATP2A3 | ATPase, Ca++ transporting, ubiquitous | Cytoplasm | transporter |
| RENR_HUMAN | ATP6AP2 | ATPase, H + transporting, lysosomal accessory protein 2 | Cytoplasm | transporter |
| ATR_HUMAN | ATR | ataxia telangiectasia and Rad3 related | Nucleus | kinase |
| B4GT7_HUMAN | B4GALT7 | xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 | Cytoplasm | enzyme |
| BEND4_HUMAN | BEND4 | BEN domain containing 4 | Other | other |
| OSTCN_HUMAN | BGLAP | bone gamma-carboxyglutamate (gla) protein | Extracellular Space | other |
| BLM_HUMAN | BLM | Bloom syndrome, RecQ helicase-like | Nucleus | enzyme |
| BRCA2_HUMAN | BRCA2 | breast cancer 2, early onset | Nucleus | transcription regulator |
| BRPF1_HUMAN | BRPF1 | bromodomain and PHD finger containing, 1 | Nucleus | transporter |
| CS068_HUMAN | C19orf68 | chromosome 19 open reading frame 68 | Other | other |
| CA174_HUMAN | C1orf174 | chromosome 1 open reading frame 174 | Nucleus | other |
| CA228_HUMAN | C1orf228 | chromosome 1 open reading frame 228 | Other | other |
| C1QC_HUMAN | C1QC | complement component 1, q subcomponent, C chain | Extracellular Space | other |
| CO3_HUMAN | C3 | complement component 3 | Extracellular Space | peptidase |
| CO4A_HUMAN | C4A/C4B | complement component 4B (Chido blood group) | Extracellular Space | other |
| C4BPA_HUMAN | C4BPA | complement component 4 binding protein, alpha | Extracellular Space | other |
| CI078_HUMAN | C9orf78 | chromosome 9 open reading frame 78 | Other | other |
| CAH3_HUMAN | CA3 | carbonic anhydrase III, muscle specific | Cytoplasm | enzyme |
| CABIN_HUMAN | CABIN1 | calcineurin binding protein 1 | Nucleus | other |
| CAND1_HUMAN | CAND1 | cullin-associated and neddylation-dissociated 1 | Cytoplasm | transcription regulator |
| CAN1_HUMAN | CAPN1 | calpain 1, (mu/I) large subunit | Cytoplasm | peptidase |
| CAN2_HUMAN | CAPN2 | calpain 2, (m/II) large subunit | Cytoplasm | peptidase |
| CASC5_HUMAN | CASC5 | cancer susceptibility candidate 5 | Nucleus | other |
| C8AP2_HUMAN | CASP8AP2 | caspase 8 associated protein 2 | Nucleus | transcription regulator |
| CC154_HUMAN | CCDC154 | coiled-coil domain containing 154 | Other | other |
| CC171_HUMAN | CCDC171 | coiled-coil domain containing 171 | Other | other |
| CCD30_HUMAN | CCDC30 | coiled-coil domain containing 30 | Other | other |
| CCD37_HUMAN | CCDC37 | coiled-coil domain containing 37 | Other | other |
| CCD80_HUMAN | CCDC80 | coiled-coil domain containing 80 | Nucleus | other |
| CCHCR_HUMAN | CCHCR1 | coiled-coil alpha-helical rod protein 1 | Cytoplasm | other |
| CENPH_HUMAN | CENPH | centromere protein H | Nucleus | other |
| CP135_HUMAN | CEP135 | centrosomal protein 135 kDa | Cytoplasm | other |
| CFAH_HUMAN | CFH | complement factor H | Extracellular Space | other |
| CHD4_HUMAN | CHD4 | chromodomain helicase DNA binding protein 4 | Nucleus | enzyme |
| CHD9_HUMAN | CHD9 | chromodomain helicase DNA binding protein 9 | Cytoplasm | other |
| ACHG_HUMAN | CHRNG | cholinergic receptor, nicotinic, gamma (muscle) | Plasma Membrane | transmembrane receptor |
| CHSTB_HUMAN | CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | Cytoplasm | enzyme |
| CHSS3_HUMAN | CHSY3 | chondroitin sulfate synthase 3 | Cytoplasm | enzyme |
| CILP1_HUMAN | CILP | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | Extracellular Space | phosphatase |
| CLNK_HUMAN | CLNK | cytokine-dependent hematopoietic cell linker | Cytoplasm | other |
| CLUS_HUMAN | CLU | clusterin | Cytoplasm | other |
| CMBL_HUMAN | CMBL | carboxymethylenebutenolidase homolog (Pseudomonas) | Cytoplasm | enzyme |
| CNO6L_HUMAN | CNOT6L | CCR4-NOT transcription complex, subunit 6-like | Cytoplasm | enzyme |
| COPA1_HUMAN | COL25A1 | collagen, type XXV, alpha 1 | Cytoplasm | other |
| CROCC_HUMAN | CROCC | ciliary rootlet coiled-coil, rootletin | Plasma Membrane | other |
| CSRN1_HUMAN | CSRNP1 | cysteine-serine-rich nuclear protein 1 | Nucleus | transcription regulator |
| DIAC_HUMAN | CTBS | chitobiase, di-N-acetyl- | Cytoplasm | enzyme |
| CUL9_HUMAN | CUL9 | cullin 9 | Cytoplasm | other |
| CWC25_HUMAN | CWC25 | CWC25 spliceosome-associated protein homolog (S. cerevisiae) | Other | other |
| CP1A2_HUMAN | CYP1A2 | cytochrome P450, family 1, subfamily A, polypeptide 2 | Cytoplasm | enzyme |
| CP51A_HUMAN | CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | Cytoplasm | enzyme |
| DAPL1_HUMAN | DAPL1 | death associated protein-like 1 | Other | other |
| DCAF6_HUMAN | DCAF6 | DDB1 and CUL4 associated factor 6 | Nucleus | transcription regulator |
| DCR1B_HUMAN | DCLRE1B | DNA cross-link repair 1B | Nucleus | enzyme |
| DCSTP_HUMAN | DCSTAMP | dendrocyte expressed seven transmembrane protein | Plasma Membrane | other |
| DCX_HUMAN | DCX | doublecortin | Cytoplasm | other |
| DDX51_HUMAN | DDX51 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 | Other | enzyme |
| DEN2D_HUMAN | DENND2D | DENN/MADD domain containing 2D | Cytoplasm | other |
| DESM_HUMAN | DES | desmin | Cytoplasm | other |
| DGAT1_HUMAN | DGAT1 | diacylglycerol O-acyltransferase 1 | Cytoplasm | enzyme |
| DGC14_HUMAN | DGCR14 | DiGeorge syndrome critical region gene 14 | Nucleus | other |
| DHX30_HUMAN | DHX30 | DEAH (Asp-Glu-Ala-His) box helicase 30 | Nucleus | enzyme |
| DIP2B_HUMAN | DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | Cytoplasm | other |
| DMXL1_HUMAN | DMXL1 | Dmx-like 1 | Extracellular Space | other |
| DYH17_HUMAN | DNAH17 | dynein, axonemal, heavy chain 17 | Cytoplasm | other |
| DYH2_HUMAN | DNAH2 | dynein, axonemal, heavy chain 2 | Other | other |
| DYH3_HUMAN | DNAH3 | dynein, axonemal, heavy chain 3 | Extracellular Space | enzyme |
| DYH5_HUMAN | DNAH5 | dynein, axonemal, heavy chain 5 | Cytoplasm | enzyme |
| DNJC7_HUMAN | DNAJC7 | DnaJ (Hsp40) homolog, subfamily C, member 7 | Cytoplasm | other |
| DOP1_HUMAN | DOPEY1 | dopey family member 1 | Cytoplasm | other |
| DSCAM_HUMAN | DSCAM | Down syndrome cell adhesion molecule | Plasma Membrane | other |
| DUS3L_HUMAN | DUS3L | dihydrouridine synthase 3-like (S. cerevisiae) | Other | other |
| DYHC2_HUMAN | DYNC2H1 | dynein, cytoplasmic 2, heavy chain 1 | Cytoplasm | other |
| COE2_HUMAN | EBF2 | early B-cell factor 2 | Nucleus | other |
| EBP_HUMAN | EBP | emopamil binding protein (sterol isomerase) | Cytoplasm | enzyme |
| EIF3C_HUMAN | EIF3C | eukaryotic translation initiation factor 3, subunit C | Other | translation regulator |
| ENPP1_HUMAN | ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | Plasma Membrane | enzyme |
| ENPP5_HUMAN | ENPP5 | ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) | Extracellular Space | enzyme |
| PERE_HUMAN | EPX | eosinophil peroxidase | Cytoplasm | enzyme |
| EXOS1_HUMAN | EXOSC1 | exosome component 1 | Nucleus | enzyme |
| F150A_HUMAN | FAM150A | family with sequence similarity 150, member A | Other | other |
| F196B_HUMAN | FAM196B | family with sequence similarity 196, member B | Other | other |
| F208B_HUMAN | FAM208B | family with sequence similarity 208, member B | Other | other |
| YV021_HUMAN | FAM230B | family with sequence similarity 230, member B (non-protein coding) | Extracellular Space | other |
| FA78B_HUMAN | FAM78B | family with sequence similarity 78, member B | Other | other |
| FBF1_HUMAN | FBF1 | Fas (TNFRSF6) binding factor 1 | Nucleus | other |
| FIBA_HUMAN | FGA | fibrinogen alpha chain | Extracellular Space | other |
| FIBB_HUMAN | FGB | fibrinogen beta chain | Extracellular Space | other |
| FR1OP_HUMAN | FGFR1OP | FGFR1 oncogene partner | Cytoplasm | kinase |
| FGRL1_HUMAN | FGFRL1 | fibroblast growth factor receptor-like 1 | Plasma Membrane | transmembrane receptor |
| FIBG_HUMAN | FGG | fibrinogen gamma chain | Extracellular Space | other |
| FHAD1_HUMAN | FHAD1 | forkhead-associated (FHA) phosphopeptide binding domain 1 | Other | other |
| FIGL2_HUMAN | FIGNL2 | fidgetin-like 2 | Other | other |
| FLNB_HUMAN | FLNB | filamin B, beta | Cytoplasm | other |
| FINC_HUMAN | FN1 | fibronectin 1 | Extracellular Space | enzyme |
| FRMD3_HUMAN | FRMD3 | FERM domain containing 3 | Other | other |
| G6PC2_HUMAN | G6PC2 | glucose-6-phosphatase, catalytic, 2 | Cytoplasm | phosphatase |
| GAK_HUMAN | GAK | cyclin G associated kinase | Nucleus | kinase |
| GSH0_HUMAN | GCLM | glutamate-cysteine ligase, modifier subunit | Cytoplasm | enzyme |
| GCN1L_HUMAN | GCN1L1 | GCN1 general control of amino-acid synthesis 1-like 1 (yeast) | Cytoplasm | translation regulator |
| CXB1_HUMAN | GJB1 | gap junction protein, beta 1, 32 kDa | Plasma Membrane | transporter |
| GLRA2_HUMAN | GLRA2 | glycine receptor, alpha 2 | Plasma Membrane | ion channel |
| GMEB1_HUMAN | GMEB1 | glucocorticoid modulatory element binding protein 1 | Nucleus | transcription regulator |
| GOGA3_HUMAN | GOLGA3 | golgin A3 | Cytoplasm | transporter |
| AATC_HUMAN | GOT1 | glutamic-oxaloacetic transaminase 1, soluble | Cytoplasm | enzyme |
| GRID2_HUMAN | GRID2 | glutamate receptor, ionotropic, delta 2 | Plasma Membrane | ion channel |
| GSAP_HUMAN | GSAP | gamma-secretase activating protein | Cytoplasm | peptidase |
| GSAS1_HUMAN | GSN-AS1 | GSN antisense RNA 1 | Other | other |
| GSHB_HUMAN | GSS | glutathione synthetase | Cytoplasm | enzyme |
| HERC1_HUMAN | HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | Cytoplasm | other |
| HES1_HUMAN | HES1 | hes family bHLH transcription factor 1 | Nucleus | transcription regulator |
| HILS1_HUMAN | HILS1 | histone linker H1 domain, spermatid-specific 1, pseudogene | Nucleus | other |
| HIP1_HUMAN | HIP1 | huntingtin interacting protein 1 | Cytoplasm | other |
| HJURP_HUMAN | HJURP | Holliday junction recognition protein | Nucleus | other |
| HPTR_HUMAN | HPR | haptoglobin-related protein | Extracellular Space | peptidase |
| 5HT2A_HUMAN | HTR2A | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled | Plasma Membrane | G-protein coupled receptor |
| I23O2_HUMAN | IDO2 | indoleamine 2,3-dioxygenase 2 | Cytoplasm | enzyme |
| GILT_HUMAN | IFI30 | interferon, gamma-inducible protein 30 | Cytoplasm | enzyme |
| IGHA1_HUMAN | IGHA1 | immunoglobulin heavy constant alpha 1 | Extracellular Space | other |
| IGHG1_HUMAN | IGHG1 | immunoglobulin heavy constant gamma 1 (G1m marker) | Extracellular Space | other |
| IGHM_HUMAN | IGHM | immunoglobulin heavy constant mu | Plasma Membrane | transmembrane receptor |
| IGJ_HUMAN | IGJ | immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides | Extracellular Space | other |
| IGKC_HUMAN | IGKC | immunoglobulin kappa constant | Extracellular Space | other |
| KV401_HUMAN | IGKV4-1 | immunoglobulin kappa variable 4-1 | Extracellular Space | other |
| LAC1_HUMAN | IGLC1 | immunoglobulin lambda constant 1 (Mcg marker) | Cytoplasm | other |
| LAC2_HUMAN | IGLC2 | immunoglobulin lambda constant 2 (Kern-Oz- marker) | Extracellular Space | other |
| IHH_HUMAN | IHH | indian hedgehog | Extracellular Space | enzyme |
| RED_HUMAN | IK | IK cytokine, down-regulator of HLA II | Extracellular Space | cytokine |
| IL1AP_HUMAN | IL1RAP | interleukin 1 receptor accessory protein | Plasma Membrane | transmembrane receptor |
| IRPL2_HUMAN | IL1RAPL2 | interleukin 1 receptor accessory protein-like 2 | Plasma Membrane | transmembrane receptor |
| IL26_HUMAN | IL26 | interleukin 26 | Extracellular Space | cytokine |
| INCE_HUMAN | INCENP | inner centromere protein antigens 135/155 kDa | Nucleus | other |
| IQCF6_HUMAN | IQCF6 | IQ motif containing F6 | Other | other |
| JARD2_HUMAN | JARID2 | jumonji, AT rich interactive domain 2 | Nucleus | transcription regulator |
| KTNB1_HUMAN | KATNB1 | katanin p80 (WD repeat containing) subunit B 1 | Cytoplasm | enzyme |
| KCND2_HUMAN | KCND2 | potassium voltage-gated channel, Shal-related subfamily, member 2 | Plasma Membrane | ion channel |
| KCNQ5_HUMAN | KCNQ5 | potassium voltage-gated channel, KQT-like subfamily, member 5 | Plasma Membrane | ion channel |
| KDM2B_HUMAN | KDM2B | lysine (K)-specific demethylase 2B | Nucleus | other |
| KDM5A_HUMAN | KDM5A | lysine (K)-specific demethylase 5A | Nucleus | transcription regulator |
| TALD3_HUMAN | KIAA0586 | KIAA0586 | Cytoplasm | other |
| K1161_HUMAN | KIAA1161 | KIAA1161 | Nucleus | other |
| KI13A_HUMAN | KIF13A | kinesin family member 13A | Cytoplasm | transporter |
| KIF19_HUMAN | KIF19 | kinesin family member 19 | Extracellular Space | enzyme |
| KIRR1_HUMAN | KIRREL | kin of IRRE like (Drosophila) | Plasma Membrane | other |
| KLC2_HUMAN | KLC2 | kinesin light chain 2 | Cytoplasm | other |
| KLRF1_HUMAN | KLRF1 | killer cell lectin-like receptor subfamily F, member 1 | Plasma Membrane | transmembrane receptor |
| LDB1_HUMAN | LDB1 | LIM domain binding 1 | Nucleus | transcription regulator |
| LHPL3_HUMAN | LHFPL3 | lipoma HMGIC fusion partner-like 3 | Other | other |
| LIPC_HUMAN | LIPC | lipase, hepatic | Extracellular Space | enzyme |
| YP023_HUMAN | LOC100128265 | uncharacterized LOC100128265 | Other | other |
| LRP1B_HUMAN | LRP1B | low density lipoprotein receptor-related protein 1B | Plasma Membrane | transmembrane receptor |
| LTBP2_HUMAN | LTBP2 | latent transforming growth factor beta binding protein 2 | Extracellular Space | other |
| LY75_HUMAN | LY75 | lymphocyte antigen 75 | Plasma Membrane | transmembrane receptor |
| MACD1_HUMAN | MACROD1 | MACRO domain containing 1 | Cytoplasm | enzyme |
| MANF_HUMAN | MANF | mesencephalic astrocyte-derived neurotrophic factor | Extracellular Space | other |
| MLP3A_HUMAN | MAP1LC3A | microtubule-associated protein 1 light chain 3 alpha | Cytoplasm | other |
| MAP4_HUMAN | MAP4 | microtubule-associated protein 4 | Cytoplasm | other |
| MA7D3_HUMAN | MAP7D3 | MAP7 domain containing 3 | Cytoplasm | other |
| MBD5_HUMAN | MBD5 | methyl-CpG binding domain protein 5 | Nucleus | other |
| MDN1_HUMAN | MDN1 | MDN1, midasin homolog (yeast) | Nucleus | other |
| MEX3B_HUMAN | MEX3B | mex-3 RNA binding family member B | Other | kinase |
| MFNG_HUMAN | MFNG | MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | Cytoplasm | enzyme |
| MKL1_HUMAN | MKL1 | megakaryoblastic leukemia (translocation) 1 | Nucleus | transcription regulator |
| MRE11_HUMAN | MRE11A | MRE11 meiotic recombination 11 homolog A (S. cerevisiae) | Nucleus | enzyme |
| RM32_HUMAN | MRPL32 | mitochondrial ribosomal protein L32 | Cytoplasm | translation regulator |
| MYBA_HUMAN | MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | Nucleus | transcription regulator |
| MYO15_HUMAN | MYO15A | myosin XVA | Cytoplasm | other |
| MYO3A_HUMAN | MYO3A | myosin IIIA | Cytoplasm | kinase |
| MYO6_HUMAN | MYO6 | myosin VI | Cytoplasm | other |
| ULA1_HUMAN | NAE1 | NEDD8 activating enzyme E1 subunit 1 | Cytoplasm | enzyme |
| NUCL_HUMAN | NCL | nucleolin | Nucleus | other |
| NCOA2_HUMAN | NCOA2 | nuclear receptor coactivator 2 | Nucleus | transcription regulator |
| NEBU_HUMAN | NEB | nebulin | Cytoplasm | other |
| NEDD4_HUMAN | NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | Cytoplasm | enzyme |
| NHS_HUMAN | NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | Nucleus | other |
| NOA1_HUMAN | NOA1 | nitric oxide associated 1 | Cytoplasm | other |
| NRX3A_HUMAN | NRXN3 | neurexin 3 | Other | transporter |
| NSD1_HUMAN | NSD1 | nuclear receptor binding SET domain protein 1 | Nucleus | transcription regulator |
| NSN5C_HUMAN | NSUN5P2 | NOP2/Sun domain family, member 5 pseudogene 2 | Other | other |
| NET5_HUMAN | NTN5 | netrin 5 | Other | other |
| NUD15_HUMAN | NUDT15 | nudix (nucleoside diphosphate linked moiety X)-type motif 15 | Cytoplasm | phosphatase |
| OBSCN_HUMAN | OBSCN | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | Cytoplasm | kinase |
| OCEL1_HUMAN | OCEL1 | occludin/ELL domain containing 1 | Other | other |
| ODFP2_HUMAN | ODF2 | outer dense fiber of sperm tails 2 | Cytoplasm | other |
| NOE2_HUMAN | OLFM2 | olfactomedin 2 | Cytoplasm | other |
| OPN4_HUMAN | OPN4 | opsin 4 | Plasma Membrane | G-protein coupled receptor |
| OR4K1_HUMAN | OR4K1 | olfactory receptor, family 4, subfamily K, member 1 | Plasma Membrane | G-protein coupled receptor |
| PALB2_HUMAN | PALB2 | partner and localizer of BRCA2 | Nucleus | other |
| PAR3L_HUMAN | PARD3B | par-3 family cell polarity regulator beta | Plasma Membrane | other |
| PARP4_HUMAN | PARP4 | poly (ADP-ribose) polymerase family, member 4 | Cytoplasm | enzyme |
| PCDH8_HUMAN | PCDH8 | protocadherin 8 | Plasma Membrane | other |
| PCLO_HUMAN | PCLO | piccolo presynaptic cytomatrix protein | Cytoplasm | transporter |
| PEAK1_HUMAN | PEAK1 | pseudopodium-enriched atypical kinase 1 | Plasma Membrane | kinase |
| PEG10_HUMAN | PEG10 | paternally expressed 10 | Nucleus | other |
| PER3_HUMAN | PER3 | period circadian clock 3 | Nucleus | other |
| PFD6_HUMAN | PFDN6 | prefoldin subunit 6 | Cytoplasm | other |
| PIGS_HUMAN | PIGS | phosphatidylinositol glycan anchor biosynthesis, class S | Cytoplasm | enzyme |
| P3C2A_HUMAN | PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | Cytoplasm | kinase |
| SOX_HUMAN | PIPOX | pipecolic acid oxidase | Cytoplasm | enzyme |
| PLCD3_HUMAN | PLCD3 | phospholipase C, delta 3 | Cytoplasm | enzyme |
| PLXA4_HUMAN | PLXNA4 | plexin A4 | Plasma Membrane | transmembrane receptor |
| PNKD_HUMAN | PNKD | paroxysmal nonkinesigenic dyskinesia | Nucleus | other |
| PNKP_HUMAN | PNKP | polynucleotide kinase 3'-phosphatase | Nucleus | kinase |
| DPOLQ_HUMAN | POLQ | polymerase (DNA directed), theta | Nucleus | enzyme |
| PMGT1_HUMAN | POMGNT1 | protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) | Cytoplasm | enzyme |
| PPIG_HUMAN | PPIG | peptidylprolyl isomerase G (cyclophilin G) | Nucleus | enzyme |
| PP12C_HUMAN | PPP1R12C | protein phosphatase 1, regulatory subunit 12C | Cytoplasm | phosphatase |
| PPT2_HUMAN | PPT2 | palmitoyl-protein thioesterase 2 | Cytoplasm | enzyme |
| PREB_HUMAN | PREB | prolactin regulatory element binding | Nucleus | transcription regulator |
| PPCEL_HUMAN | PREPL | prolyl endopeptidase-like | Other | peptidase |
| PRG4_HUMAN | PRG4 | proteoglycan 4 | Extracellular Space | other |
| PRP31_HUMAN | PRPF31 | pre-mRNA processing factor 31 | Nucleus | other |
| PRC2A_HUMAN | PRRC2A | proline-rich coiled-coil 2A | Cytoplasm | other |
| PSB3_HUMAN | PSMB3 | proteasome (prosome, macropain) subunit, beta type, 3 | Cytoplasm | peptidase |
| PRS7_HUMAN | PSMC2 | proteasome (prosome, macropain) 26S subunit, ATPase, 2 | Nucleus | peptidase |
| PTPRM_HUMAN | PTPRM | protein tyrosine phosphatase, receptor type, M | Plasma Membrane | phosphatase |
| PTTG3_HUMAN | PTTG3P | pituitary tumor-transforming 3, pseudogene | Other | other |
| PZP_HUMAN | PZP | pregnancy-zone protein | Extracellular Space | other |
| RAB10_HUMAN | RAB10 | RAB10, member RAS oncogene family | Cytoplasm | enzyme |
| RB3GP_HUMAN | RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | Cytoplasm | other |
| RAB6A_HUMAN | RAB6A | RAB6A, member RAS oncogene family | Cytoplasm | enzyme |
| RAB8B_HUMAN | RAB8B | RAB8B, member RAS oncogene family | Cytoplasm | enzyme |
| RGPA2_HUMAN | RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | Cytoplasm | other |
| RBM23_HUMAN | RBM23 | RNA binding motif protein 23 | Nucleus | other |
| REG1A_HUMAN | REG1A | regenerating islet-derived 1 alpha | Extracellular Space | growth factor |
| RELN_HUMAN | RELN | reelin | Extracellular Space | peptidase |
| RFC4_HUMAN | RFC4 | replication factor C (activator 1) 4, 37 kDa | Nucleus | other |
| RFX8_HUMAN | RFX8 | RFX family member 8, lacking RFX DNA binding domain | Other | other |
| RMND1_HUMAN | RMND1 | required for meiotic nuclear division 1 homolog (S. cerevisiae) | Cytoplasm | other |
| RNF17_HUMAN | RNF17 | ring finger protein 17 | Cytoplasm | other |
| RN213_HUMAN | RNF213 | ring finger protein 213 | Cytoplasm | enzyme |
| RN219_HUMAN | RNF219 | ring finger protein 219 | Other | other |
| FTM_HUMAN | RPGRIP1L | RPGRIP1-like | Cytoplasm | other |
| RL29_HUMAN | RPL29 | ribosomal protein L29 | Cytoplasm | other |
| RL37_HUMAN | RPL37 | ribosomal protein L37 | Cytoplasm | other |
| KS6A4_HUMAN | RPS6KA4 | ribosomal protein S6 kinase, 90 kDa, polypeptide 4 | Cytoplasm | kinase |
| RTKN_HUMAN | RTKN | rhotekin | Cytoplasm | other |
| RYR2_HUMAN | RYR2 | ryanodine receptor 2 (cardiac) | Plasma Membrane | ion channel |
| SAMD8_HUMAN | SAMD8 | sterile alpha motif domain containing 8 | Cytoplasm | other |
| SASH1_HUMAN | SASH1 | SAM and SH3 domain containing 1 | Extracellular Space | other |
| UTER_HUMAN | SCGB1A1 | secretoglobin, family 1A, member 1 (uteroglobin) | Extracellular Space | cytokine |
| SCUB3_HUMAN | SCUBE3 | signal peptide, CUB domain, EGF-like 3 | Plasma Membrane | other |
| SPB9_HUMAN | SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | Cytoplasm | other |
| SET1A_HUMAN | SETD1A | SET domain containing 1A | Nucleus | ion channel |
| SHAN1_HUMAN | SHANK1 | SH3 and multiple ankyrin repeat domains 1 | Cytoplasm | other |
| SHAN3_HUMAN | SHANK3 | SH3 and multiple ankyrin repeat domains 3 | Plasma Membrane | other |
| CTL1_HUMAN | SLC44A1 | solute carrier family 44 (choline transporter), member 1 | Plasma Membrane | transporter |
| SNTAN_HUMAN | SNTN | sentan, cilia apical structure protein | Other | other |
| SOLH1_HUMAN | SOHLH1 | spermatogenesis and oogenesis specific basic helix-loop-helix 1 | Cytoplasm | transcription regulator |
| SPAG7_HUMAN | SPAG7 | sperm associated antigen 7 | Nucleus | other |
| SPA2L_HUMAN | SPATA2L | spermatogenesis associated 2-like | Other | other |
| CYTSB_HUMAN | SPECC1 | sperm antigen with calponin homology and coiled-coil domains 1 | Nucleus | other |
| SPO11_HUMAN | SPO11 | SPO11 meiotic protein covalently bound to DSB | Nucleus | enzyme |
| SPTN5_HUMAN | SPTBN5 | spectrin, beta, non-erythrocytic 5 | Plasma Membrane | other |
| SRGP2_HUMAN | SRGAP2 | SLIT-ROBO Rho GTPase activating protein 2 | Cytoplasm | other |
| SRG2C_HUMAN | SRGAP2C | SLIT-ROBO Rho GTPase activating protein 2C | Other | other |
| SIA7B_HUMAN | ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | Cytoplasm | enzyme |
| STXB1_HUMAN | STXBP1 | syntaxin binding protein 1 | Cytoplasm | transporter |
| SP20H_HUMAN | SUPT20H | suppressor of Ty 20 homolog (S. cerevisiae) | Nucleus | other |
| SPT6H_HUMAN | SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | Nucleus | transcription regulator |
| SVEP1_HUMAN | SVEP1 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 | Cytoplasm | other |
| SYNJ1_HUMAN | SYNJ1 | synaptojanin 1 | Cytoplasm | phosphatase |
| TADA3_HUMAN | TADA3 | transcriptional adaptor 3 | Nucleus | transcription regulator |
| TBX20_HUMAN | TBX20 | T-box 20 | Nucleus | transcription regulator |
| TDRD1_HUMAN | TDRD1 | tudor domain containing 1 | Cytoplasm | other |
| TET1_HUMAN | TET1 | tet methylcytosine dioxygenase 1 | Nucleus | other |
| THMS1_HUMAN | THEMIS | thymocyte selection associated | Cytoplasm | other |
| TLK2_HUMAN | TLK2 | tousled-like kinase 2 | Cytoplasm | kinase |
| TM131_HUMAN | TMEM131 | transmembrane protein 131 | Extracellular Space | other |
| T132C_HUMAN | TMEM132C | transmembrane protein 132C | Other | other |
| T151A_HUMAN | TMEM151A | transmembrane protein 151A | Other | other |
| TM232_HUMAN | TMEM232 | transmembrane protein 232 | Other | other |
| TNFA_HUMAN | TNF | tumor necrosis factor | Extracellular Space | cytokine |
| TPD54_HUMAN | TPD52L2 | tumor protein D52-like 2 | Cytoplasm | other |
| TRML4_HUMAN | TREML4 | triggering receptor expressed on myeloid cells-like 4 | Other | other |
| TRI32_HUMAN | TRIM32 | tripartite motif containing 32 | Nucleus | transcription regulator |
| TRI65_HUMAN | TRIM65 | tripartite motif containing 65 | Other | other |
| TARA_HUMAN | TRIOBP | TRIO and F-actin binding protein | Nucleus | other |
| TRIPB_HUMAN | TRIP11 | thyroid hormone receptor interactor 11 | Cytoplasm | transcription regulator |
| TROAP_HUMAN | TROAP | trophinin associated protein | Cytoplasm | peptidase |
| TRPC5_HUMAN | TRPC5 | transient receptor potential cation channel, subfamily C, member 5 | Plasma Membrane | ion channel |
| TSG13_HUMAN | TSGA13 | testis specific, 13 | Other | other |
| TTC12_HUMAN | TTC12 | tetratricopeptide repeat domain 12 | Other | other |
| TITIN_HUMAN | TTN | titin | Cytoplasm | kinase |
| GCP6_HUMAN | TUBGCP6 | tubulin, gamma complex associated protein 6 | Cytoplasm | other |
| TRXR3_HUMAN | TXNRD3 | thioredoxin reductase 3 | Cytoplasm | enzyme |
| UBQLN_HUMAN | UBQLNL | ubiquilin-like | Other | other |
| UCKL1_HUMAN | UCKL1 | uridine-cytidine kinase 1-like 1 | Cytoplasm | kinase |
| UGDH_HUMAN | UGDH | UDP-glucose 6-dehydrogenase | Nucleus | enzyme |
| USP9X_HUMAN | USP9X | ubiquitin specific peptidase 9, X-linked | Plasma Membrane | peptidase |
| UTRO_HUMAN | UTRN | utrophin | Plasma Membrane | transmembrane receptor |
| VP13C_HUMAN | VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | Cytoplasm | other |
| WAC_HUMAN | WAC | WW domain containing adaptor with coiled-coil | Nucleus | other |
| WDR1_HUMAN | WDR1 | WD repeat domain 1 | Extracellular Space | other |
| WDR35_HUMAN | WDR35 | WD repeat domain 35 | Cytoplasm | other |
| WDR43_HUMAN | WDR43 | WD repeat domain 43 | Nucleus | other |
| WFDC3_HUMAN | WFDC3 | WAP four-disulfide core domain 3 | Extracellular Space | other |
| YIPF1_HUMAN | YIPF1 | Yip1 domain family, member 1 | Cytoplasm | other |
| NIPA_HUMAN | ZC3HC1 | zinc finger, C3HC-type containing 1 | Nucleus | other |
| ZFHX4_HUMAN | ZFHX4 | zinc finger homeobox 4 | Extracellular Space | other |
| ZF64B_HUMAN | ZFP64 | ZFP64 zinc finger protein | Nucleus | other |
| ZN132_HUMAN | ZNF132 | zinc finger protein 132 | Nucleus | other |
| ZNF14_HUMAN | ZNF14 | zinc finger protein 14 | Nucleus | transcription regulator |
| ZN215_HUMAN | ZNF215 | zinc finger protein 215 | Nucleus | transcription regulator |
| Z286B_HUMAN | ZNF286B | zinc finger protein 286B | Other | other |
| ZN345_HUMAN | ZNF345 | zinc finger protein 345 | Nucleus | transcription regulator |
| ZN532_HUMAN | ZNF532 | zinc finger protein 532 | Other | other |
| ZN561_HUMAN | ZNF561 | zinc finger protein 561 | Nucleus | other |
| ZN624_HUMAN | ZNF624 | zinc finger protein 624 | Nucleus | other |
| ZNF74_HUMAN | ZNF74 | zinc finger protein 74 | Nucleus | other |
List of common exosomal proteins are presented as Protein ID, Symbol, Entrez Gene Name, Location and type. No significant differences were observed en exosomal protein content from fresh or frozen plasma (coefficient of variation < 5%) after different freeze thawing cycle from the same sample.