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Biochemical synthesis of melatonin. Tryptophan acts as a precursor for melatonin synthesis. AAD is responsible for the conversion of 5-hydroxytryptophan into serotonin. Melatonin is formed from serotonin through a phase of reaction with the help of two enzymes, AANAT and HIOMT. Acetylation of serotonin occurs with the action of AANAT which forms N-acetylserotonin and subsequently HIOMT converts N-acetylserotonin into melatonin.
