Figure 1.

Time course of CD93 and GIPC expression in a rat model of brain inflammation.

(A) Protein expression profiles of CD93, GIPC, iNOS, and the internal reference β-actin in sham surgery, control and experimental groups (at 2, 4, 6, 9, 12, and 24 hours). (B) Statistical results of A: each column represents the ratio of target protein to β-actin at various time points. *P < 0.05, **P < 0.01, vs. sham surgery group (sham). Data are expressed as the mean ± SEM with four rats in each group; one-way analysis of variance and the least significant difference tests were performed. iNOS expression was significantly increased at 4, 6, 9, and 24 hours, and peaked at 12 hours. CD93 immunoreactivity was significantly increased at 2 hours, and then gradually reduced (remaining significant at 9, 12, and 24 hours). GIPC expression was not altered at any time point. GIPC: GAIP-interacting protein, C terminus; iNOS: inducible nitric oxide synthase; LPS: Lipopolysaccharide; h: hours.