Table II. Desmopressin doses and response for VWD.
Route of administration | Suggested formulation | Dose | Peak levels achieved |
---|---|---|---|
Intravenous infusion over 30-60 min | 4 μg/ml diluted in 100ml 0.9%NaCl for infusion | 0.3 μg/kg [maximum dose 28 μg] | 15 min after infusion completed |
Subcutaneous | 15 μg/ml | 0.3 μg/kg [maximum dose 28 μg] | 60-90 min after injection |
Intranasal | 150 μg per metered spray | > 50 kg: 150 μg spray to each nostril ≤ 50 kg: single 150 μg spray |
1-4 h after administration |