Table 1.
Mean ± SD physiologic data for the four groups: untreated wild-type (uWT), treated wild-type (tWT), untreated Myh11R247C/R247C (uR247C), and treated Myh11R247C/R247C (tR247C), where treatment combined L-NAME and high salt for 18 weeks beginning at 8 to 9 weeks of age.
uWT | tWT | uR247C | tR247C | |
---|---|---|---|---|
Number of Animals | 5 | 5 | 5 | 8 |
Age (weeks) | 27.3 ± 1.0 | 26.7 ± 1.0 | 26.0 ± 2.0 | 26.9 ± 1.4 |
Body Mass (g) | 27.4 ± 4.3 | 27.2 ± 4.0 | 29.0 ± 2.6 | 23.6 ± 2.4 |
Blood Pressure (mmHg) | ||||
Diastolic | 91 ± 6 | 127 ± 8* | 82 ± 2 | 141 ± 18* |
Systolic | 124 ± 7 | 175 ± 12* | 117 ± 3 | 185 ± 16* |
p < 0.05 between treated and untreated mice with the same genotype.