Table 3.

Material parameters estimated by fitting the microstructurally motivated constitutive relation (Appendix 1) to average datasets (excluding outliers) for the ascending thoracic aorta (ATA) and proximal descending thoracic aorta (DTA) from untreated wild-type (uWT), treated wild-type (tWT), untreated R247C mutant (uR247C), and treated R247C mutant (tR247C) mice. RMSE denotes the root mean sum-of-the-squares of the error for the regression. Although individual parameters can be compared across groups, better interpretations come from resulting values of the linearized stiffness and stored energy (cf. Figures 3 and 5).

	c (kPa)	$c_1^1$ (kPa)	$c_2^1$ (−)	$c_1^2$ (kPa)	$c_2^2$ (−)	$c_1^{3,4}$ (kPa)	$c_2^{3,4}$ (−)	α0 (deg)	RSME (−)
ATA
uWT	32.38	12.67	0.04	15.00	0.24	4.57	0.50	42.08	0.060
tWT	29.06	9.54	0.10	14.40	0.47	3.50	0.82	41.76	0.053
uR247C	20.01	6.62	0.12	16.02	0.16	3.70	0.40	41.31	0.064
tR247C	26.10	6.89	0.19	20.94	0.26	5.69	0.63	41.25	0.058
DTA
uWT	45.17	0.65	1.60	13.14	0.64	0.20	2.50	30.75	0.061
tWT	33.73	2.96	1.26	14.04	0.48	0.27	2.53	28.57	0.054
uR247C	36.19	4.66	0.34	23.21	0.25	0.27	2.26	26.85	0.087
tR247C	28.25	2.11	0.99	18.18	0.36	1.12	1.46	25.52	0.078