Table 2.
Incidence of commonly encountered toxicities
| 3-AP dose cohorts: no. of patients (%)
|
||||
|---|---|---|---|---|
| 50 mg/m2, N=7 | 75 mg/m2, N=15 | 100 mg/m2, N=3 | All patients, N=25 | |
| Toxicity | ||||
| Nausea/vomiting | ||||
| Grade 1/2 | 7 | 8 | 3 | 18 (72) |
| Grade 3/4 | 0 | 0 | 0 | 0 |
| Fever | ||||
| Grade1/2 | 5 | 8 | 0 | 13 (52) |
| Grade3/4 | 0 | 0 | 0 | 0 |
| Diarrhea | ||||
| Grade1/2 | 4 | 6 | 2 | 12(48) |
| Grade3/4 | 0 | 0 | 0 | 0 |
| Rash | ||||
| Grade1/2 | 2 | 4 | 1 | 7 (28) |
| Grade 3/4 | 2 | 0 | 0 | 2 (8) |
| Mucositis | ||||
| Grade1/2 | 3 | 5 | 1 | 9 (36) |
| Grade 3/4 | 0 | 0 | 0 | 0 |
| LFTs | ||||
| Grade 1/2 | 0 | 0 | 0 | 0 |
| Grade 3/4 | 1 | 1 | 1 | 3 (12) |
| Cerebellar | ||||
| Grade 1/2 | 0 | 0 | 0 | 0 |
| Grade 3/4 | 0 | 2a | 0 | 2 (8) |
a
Denotes dose-limiting cerebellar toxicity occurring in two patients