Table 3.
3-AP dose and methemoglobinemia
| Pt # | 3-AP dose (mg/m2) | Baseline SaO2 (%) | Post 3-AP SaO2 (%) | Peak Met- Hg (%) | Trough Met-Hg (%) |
|---|---|---|---|---|---|
| 12 | 100 | 94 | 88 | 17.6 | 0.8 |
| 12 | 75 | 96 | 90 | 13 | 1.1 |
| 13 | 100 | 96 | 92 | ND | ND |
| 14 | 100 | 96 | 89 | 17.8 | 1.4 |
| 14 | 75 | 98 | 92 | 14.1 | 1.8 |
| 15 | 75 | 96 | 88 | 15.7 | 1.5 |
| 16 | 75 | 96 | 90 | 13.5 | 1.6 |
| 17 | 75 | 98 | 94 | 15.7 | 1.4 |
| 18 | 75 | 97 | 89 | 10.5 | 1.7 |
| 19 | 75 | 97 | 90 | 10.3 | 1.4 |
| 20 | 75 | 95 | 92 | 15.2 | 1.7 |
| 21 | 75 | 99 | 91 | 15.4 | 0.9 |
| 22a | 75 | 98 | 91 | 10.1 | 1.5 |
| 23 | 75 | 96 | 92 | 17.9 | 3.2 |
| 24 | 75 | 96 | 86 | 12.9 | 1.0 |
| 25a | 75 | 95 | 88 | 15.3 | 1.3 |
ND: not done; Baseline O2 sat-pulse oximeter reading prior to initial 3-AP dose, Peak met-Hg: met-Hg recorded within 2 h of completion of initial 3-AP infusion, Post 3-AP SaO2: pulse oximeter reading that coincides with peak met-Hg level, Trough met-Hg: met-Hg level 24 h post initial 3-AP infusion
a
Developed symptoms of ataxia, agitation, tremors, dysmetria