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. 2015 Jan 5;5:510. doi: 10.3389/fphys.2014.00510

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Copyright © 2015 Babajko, de La Dure-Molla, Jedeon and Berdal.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Amelogenin production in 21-day old Msx2−/− mice showing ameloblast cell secretory disorders in more detail (Molla et al., 2010). In this condition, the polarity of the entire enamel organ is completely lost. (A) Epithelial cells appear to delaminate losing their orientation and intercellular cohesion (scale bars: 20 μm). (B) The apparent level of amelogenin RNA synthesis is uniformly low in the entire enamel organ. The resulting ameloblasts do not produce significant amounts of enamel matrix (scale bars: 100 μm).