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. Author manuscript; available in PMC: 2015 Jan 5.
Published in final edited form as: Adv Neurobiol. 2014;11:171–188. doi: 10.1007/978-3-319-08894-5_9

Fig. 1.

Fig. 1

Targeted overexpression of HSP72 in astrocytes reduces delayed CA1 neuronal death and preserves GLT-1 expression. A: GFAPp-HSP72 or control DNA was injected stereotaxically just above CA1 on one side (black arrow for microinjection track) two days before forebrain ischemia. Selective loss of CA1 hippocampal neurons (between white arrows in middle and lower panels) was observed at seven days reperfusion by cresyl violet staining. The loss of CA1 hippocampal neurons was significantly reduced on the HSP72 injected side compared with the noninjected side (lower panel) or the control DNA injected hippocampus (middle panel). B: GLT-1 immunoreactivity was significantly greater after GFAPp-HSP72 injection compared with control after 10 min ischemia and 5 hour reperfusion. Propidium iodide (PI) labels cell nuclei. Modified from Figs. 2 and 3 in Xu et al. (2010).