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. 2015 Jan 5;5:664. doi: 10.3389/fimmu.2014.00664

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Copyright © 2015 Rath, Baker, Pyzik and Blumberg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FcRn-mediated functions in immune surveillance and homeostasis at the intestinal epithelial barrier (16, 31, 34). FcRn within enterocytes can transport IgG from the systemic circulation across the epithelial barrier into the intestinal lumen (I.). Upon formation of immune complexes (ICs) consisting of bacteria and anti-bacterial IgG within the intestinal lumen, FcRn can transcytose these back into the LP (II.). In the LP, the ICs are delivered to antigen-presenting cells (APCs) from which the ICs are taken up via canonical FcγR’s. Once internalized into the cell, the ICs are then directed into acidic endosomes, in which FcRn is operative to mediate the presentation of IC derived antigen to antigen-specific T-cells (III.).