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. 2013 Oct 4;74(1):196–203. doi: 10.1136/annrheumdis-2013-203972

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(A) Non-Arthritic: Knee joint of control, non-arthritic mouse. Boxed region (left) is enlarged (right) and demonstrates a large blood vessel penetrating through bone and into the marrow space in the region of anterior cruciate ligament/posterior cruciate ligament attachment. (B) tartrate-resistant acid phosphatase (TRAP) stain shows TRAP activity at this site. (C) Arthritic: Boxed region (left) shows similar anatomic region to that shown in A and B and is enlarged (right). Inflammatory tissue enters the bone marrow space via blood vessel channel. (D) TRAP stain shows TRAP expressing cells at interface between inflammation and bone.