Table 2.
Risk of Coronary Heart Disease (CHD) Mortality in Men According to Physical Activity Score: 1998–2000
| Outcome | None, n = 233 | Occasional, n = 604 | Light, n = 502 | Moderate, n = 407 | Moderately Vigorous and Vigorous, n = 895 | Total, N = 2,641 | P (Trend) |
|---|---|---|---|---|---|---|---|
| First CHD event (fatal or nonfatal) | |||||||
| CHD fatal or nonfatal events, n | 37 | 55 | 43 | 35 | 66 | 236 | |
| CHD event rate/1,000 | 18.9 | 9.5 | 8.7 | 8.6 | 7.4 | 9.2 | |
| HR (95% CI) | |||||||
| Model 1 | 1 | 0.52 (0.34–0.79) | 0.47 (0.30–0.74) | 0.51 (0.32–0.82) | 0.44 (0.29–0.65) | .004 | |
| Model 2 | 1 | 0.53 (0.34–0.81) | 0.48 (0.31–0.75) | 0.55 (0.34–0.89) | 0.48 (0.31–0.73) | .02 | |
| Model 3 | 1 | 0.54 (0.35–0.83) | 0.50 (0.32–0.78) | 0.57 (0.36–0.93) | 0.50 (0.33–0.76) | .04 | |
| Model 4 | 1 | 0.53 (0.35–0.81) | 0.50 (0.32–0.78) | 0.57 (0.35–0.92) | 0.51 (0.33–0.78) | .05 | |
| Fatal CHD | |||||||
| CHD fatal events, n | 21 | 39 | 23 | 19 | 34 | 136 | |
| CHD mortality/1,000 | 10.3 | 6.6 | 4.5 | 4.5 | 3.7 | 5.1 | |
| HR (95% CI) | |||||||
| Model 1 | 1 | 0.68 (0.40–1.16) | 0.46 (0.26–0.84) | 0.55 (0.29–1.02) | 0.43 (0.25–0.75) | .005 | |
| Model 2 | 1 | 0.73 (0.42–1.25) | 0.51 (0.28–0.94) | 0.67 (0.35–1.27) | 0.52 (0.29–0.92) | .04 | |
| Model 3 | 1 | 0.78 (0.45–1.36) | 0.57 (0.31–1.05) | 0.74 (0.39–1.41) | 0.58 (0.33–1.03) | .09 | |
| Model 4 | 1 | 0.76 (0.44–1.32) | 0.57 (0.31–1.05) | 0.73 (0.38–1.39) | 0.61 (0.34–1.08) | .14 | |
| All-cause mortality | |||||||
| Deaths, n | 110 | 192 | 118 | 88 | 202 | 710 | |
| Mortality/1,000 | 54.1 | 32.7 | 23.3 | 21.1 | 22.2 | 27.0 | |
| HR (95% CI) | |||||||
| Model 1 | 1 | 0.61 (0.48–0.77) | 0.43 (0.33–0.56) | 0.44 (0.33–0.59) | 0.45 (0.35–0.57) | <.001 | |
| Model 2 | 1 | 0.67 (0.53–0.85) | 0.49 (0.38–0.65) | 0.53 (0.40–0.71) | 0.57 (0.45–0.73) | <.001 | |
| Model 3 | 1 | 0.71 (0.56–0.91) | 0.55 (0.42–0.71) | 0.58 (0.43–0.78) | 0.63 (0.49–0.81) | .003 | |
| Model 4 | 1 | 0.69 (0.54–0.88) | 0.52 (0.40–0.68) | 0.56 (0.42–0.75) | 0.63 (0.49–0.80) | .004 | |
Model 1 = age and region.
Model 2 = model 1 plus alcohol intake, smoking history, plasma vitamin C, social class, total cholesterol, high-density lipoprotein cholesterol, triglycerides, systolic blood pressure, waist circumference, forced expiratory volume in 1 second, estimated glomerular filtration rate, depression, and diabetes mellitus.
Model 3 = Model 2 plus C-reactive protein, von Willebrand factor, and D-dimer.
Model 4 = Model 2 plus N-terminal pro-brain natriuretic peptide.
HR = Hazard Ratio; CI = Confidence Interval.