Table 1.

Changes in the number of extended-release oxycodone (ERO) exposures per quarter reported to US poison centers from 1 year before to 2 years after introduction of reformulated ERO by reasons for exposure

	Pre-reformulation (average per quarter)	Post-reformulation (average per quarter)	Change (post–pre) %	95%CI	p value
Extended-release oxycodone
All exposures	692.8	509.4	−26	(−28, −20)	<0.0001
–Intentional	390.5	292.5	−25	(−26, −16)	<0.0001
–Abuse	130.3	83.3	−36	(−40, −23)	<0.0001
–Suspected suicide	182.3	143.1	−21	(−26, −10)	<0.0001
–Misuse	51.3	40.4	−21	(−29, 2)	0.0076
–Unintentional	242.5	180.9	−25	(−31, −18)	<0.0001
–Misuse	5.3	3.9	−26	(−58, 37)	0.2826
–General	75.0	45.9	−39	(−49, −29)	<0.0001
–Therapeutic errors	161.3	129.4	−20	(−26, −9)	<0.0001
–Adverse reactions	29.8	19.5	−34	(−50, −17)	0.0005
–Withdrawal	13.5	4.5	−67	(−74, −37)	<0.0001
–Unknown	42.8	38.3	−11	(−24, 12)	0.244
Other single-entity oxycodone
All exposures	1448.8	1670.3	15	(12, 20)	<0.0001
–Intentional	887.5	1042.4	17	(14, 24)	<0.0001
–Abuse	228.5	273.4	20	(13, 33)	<0.0001
–Suspected suicide	477.8	553.4	16	(10, 23)	<0.0001
–Misuse	104.0	119.6	15	(5, 34)	0.0172
–Unintentional	427.8	471.4	10	(3, 16)	0.0009
–Misuse	8.5	12.0	41	(2, 129)	0.0840
–General	189.5	189.4	0	(−9, 10)	0.9882
–Therapeutic errors	223.0	264.5	19	(7, 26)	<0.0001
–Adverse reactions	74.3	85.8	15	(1, 34)	0.0382
–Withdrawal	14.3	14.9	4	(−26, 44)	0.7899
–Unknown	125.3	153.6	23	(11, 36)	0.0005
Heroin
All exposures	587.3	806.5	37	(22, 35)	<0.0001
–Intentional	527.3	726.1	38	(22, 36)	<0.0001
–Abuse	355.8	505.1	42	(24, 41)	<0.0001
–Suspected suicide	100.8	130.4	29	(9, 39)	<0.0001
–Misuse	46.5	60.4	30	(3, 47)	0.0025
–Unintentional	28.0	34.5	23	(−6, 49)	0.0624
–Misuse	2.0	3.5	75	(−61, 107)	0.1627
–General	22.3	27.0	21	(−6, 57)	0.1245
–Therapeutic errors	0.8	0.6	−17	(−83, 498)	0.8029
–Adverse reactions	2.0	7.9	294	(60, 629)	0.0003
–Withdrawal	15.8	18.1	15	(−28, 37)	0.3520
–Unknown	35.0	44.5	27	(5, 55)	0.0161