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. 2014 Nov 28;70(1):80–89. doi: 10.1111/all.12536

Figure 3.

Figure 3

Disruption of alveolar macrophage-directed homeostasis promotes an increase in interstitial lung tissue macrophages and enhances the systemic immune response following HDM mucosal challenge (A) Total tissue leukocytes and (B) lung interstitial macrophages quantified by flow cytometry. (C) FACS plots depicting lung alveolar and interstitial macrophage populations. (D) Total IgE, (E) HDM-specific IgE, (F) HDM-specific IgG1, and (G) HDM-specific IgG2a in serum following clodronate treatment during sensitization quantified by ELISA. *P < 0.05, **P < 0.01, and ***P < 0.001 relative to PBS control group by Mann–Whitney U-test, n = 6–8.