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. Author manuscript; available in PMC: 2015 Jan 5.
Published in final edited form as: Thromb Haemost. 2012 Nov 22;109(1):53–60. doi: 10.1160/TH12-05-0316

Figure 2. Effect of elevated FVIII levels on time to clot initiation and rate of clot formation.

Figure 2

FVIII levels were elevated in human FVIII deficient plasma through the addition of rhFVIII. Coagulation was stimulated through the addition of tissue factor and calcium chloride and two TEG parameters examined: R-value and α angle. (A) Time to clot initiation. Elevated FVIII levels significantly decreased the R-value, which is indicative of time to clot initiation (P<.001, one way ANOVA). Each symbol represents one sample. (B) Rate of clot formation. Elevated FVIII levels significantly increased the α angle, which is indicative of the rate of fibrin formation and an indirect measure of the rate of clot formation (P<.001, one way ANOVA). Each symbol represents one sample.