What is known on this topic? Elevated FVIII levels are an independent risk factor for the development of venous thrombosis; however, a direct pathogenic role for elevated FVIII levels in arterial thrombosis has not been documented.

What this paper adds? FVIII levels must be elevated significantly above physiological levels to increase arterial thrombogenic risk. The contribution of transient elevations in FVIII levels in the development of arterial thrombosis is small.