Skip to main content
. Author manuscript; available in PMC: 2015 Jan 5.
Published in final edited form as: Austin Alzheimers Parkinsons Dis. 2014;1(2):id1008.

Figure 1. APP binds to AppBp1 in a region that mediates adenylation and nedd8 binding to NAE.

Figure 1

A. C-terminal sequence of APP695 showing the C-terminus of Aβ40 and Aβ42, lysine residues (purple) that can be neddylated and the AppBp1 binding sites in APP AICD region (yellow lines). B. Diagram of conserved domains between NAE and Uba1. The APP-binding site, AppBp1 (145-251) as indicated was identified by Chow et al. [28]. The domains in AppBp1, Uba3, and Uba1 are drawn based on Schulman and Harper's review [38].