. Author manuscript; available in PMC: 2015 Jan 5.

Published in final edited form as: Austin Alzheimers Parkinsons Dis. 2014;1(2):id1008.

Table 1.

Examples of the cell cycle proteins degraded by NAE-activated Cullin ubiquitin ligases.

NAE Targets	Function in Cell Cycle	Cullin Ubiquitin Ligase involved	Protein changes in AD brains
Cyclin B	Essential in entry into mitosis [93]	Cul1/ SCF [94]	Increased [95-99]
Cyclin D	Promotes G1-S transition [100]	Cul1/SCF(Fbxw8) [101] Cul1/SCF(Fbx4)[102]	Increased [96,99]
Cyclin E	Endorepilcation in placenta trophoblast giant cells [103]	Cul3 [104] Cul1/SCF (Skp2) [105-107] Cul1/SCF(Fbw7) [108]	Increased [97]
Cdc25a	Promote G2-M transistion [109]	Cul1/SCF(β-TrCP) [110]	Activated [111]
p27(kip1)	Nuclear p27 inhibit G1 Phase progression [112,113] Cytoplasmic p27 negatively regulates migration [114,115]	Cul1/SCF [105,116] Cul4 [117]	Increased [118]