Table 4.

Outcome data

	3 Years		5 Years		HR (95% CI), P-value
	Estimate %	95% Confidence Interval	Estimate %	95% Confidence Interval
RFS
Total	79	74–84	60	52–67
Treated HR	87	79–92	73	62–81	0.68 (0.54, 0.86), P = 0.001
Not treated HR	74	66–80	51	40–60
NCI-SR	76	67–83	48	35–59	0.65 (0.43, 1.00), P = 0.048
NCI-HR	83	76–89	69	59–77
EFS
Total	77	71–82	58	51–65
Treated HR	84	75–89	70	59–78	0.73 (0.59, 0.91), P = 0.005
Not treated HR	72	64–79	50	39–59
NCI-SR	74	65–81	47	35–58	0.71 (0.47, 1.05), P = 0.089
NCI-HR	80	72–86	66	57–74
OS
Total	91	86–94	82	76–87
Treated HR	89	81–93	83	74–90	0.97 (0.72, 1.30), P = 0.829
Not treated HR	92	86–95	81	72–87
NCI-SR	92	85–96	81	71–88	1.12 (0.63, 2.00), P = 0.688
NCI-HR	89	83–94	82	74–88

Abbreviations: CI, confidence interval; EFS, event-free survival; HR, hazard ratio; NCI, National Cancer Institute; NCI-HR, NCI high risk; OS, overall survival; RFS, relapse-free survival; SR, standard risk. RFS (median follow-up time 3.5 years). EFS (median follow-up time 3.4 years). OS (median follow-up time 4.0 years).