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. 2015 Jan 5;5:7626. doi: 10.1038/srep07626

Figure 3. LBH inhibits NF-κB transcriptional activity.

Figure 3

(a) NF-κB-Luc reporter plasmid was co-transfected with the pRL-SV40 plasmid into CNE1-LBH and CNE1-NC control cells. The relative luciferase unit (RLU) at indicated time points post-transfection showed that the NF-κB transcriptional activity decreased in CNE1-LBH cells (*P < 0.05 vs. CNE1-NC group). (b) NF-κB transcriptional activity significantly increased after LBH knockdown in NP69 cells (*P < 0.05 vs. NP69-NC-siRNA group). (c) IκB phosphorylation was increased in CNE1-LBH compared to CNE1-NC, and (d) P65 phosphorylation was correspondingly downregulated.