Table 2.

Comparison of PVL^* Volume and Count for Four Anatomical Regions for RRMS and CIS versus Migraine Patients.

PVL Location	PVL Volume** or Count	RRMS (n=36)		CIS (n=10)		Migraine (n=32)
		Mean ± SEM (mm3)	P-value (RR-MS vs Migraine)	Mean ± SEM (mm3)	P-value (CIS vs Migraine)	Mean ± SEM (mm3)
T2WI
Anterior Horn	Volume	268.2 ± 39.04	0.2589	225.7 ± 64.84	0.7788	200.8 ± 44.87
Anterior Horn	Count	1.583 ± 0.1457	0.3477	1.600 ± 0.3712	0.5376	1.375 ± 0.1665
Posterior Horn	Volume	470.4 ± 90.61	0.0325***	829.5 ± 437.6	0.0228	250.6 ± 31.32
Posterior Horn	Count	1.306 ± 0.1248	0.2228	1.500 ± 0.2687	0.9127	1.531 ± 0.1346
Body of Lateral	Volume	838.5 ± 178.8	0.0005	857.5 ± 509.6	0.0149	138.3 ± 30.90
Ventricles
Body of Lateral	Count	2.444 ± 0.3198	0.0002	1.500 ± 0.4534	0.1657	0.9375 ± 0.1735
Ventricles
Temporal Horn	Volume	16.28 ± 9.756	0.133	15.53 ± 11.06	0.4066	69.92 ± 35.79
Temporal Horn	Count	0.139 ± 0.070	0.0097	0.2000 ± 0.1333	0.1986	0.5313± 0.1346
FLAIR
Anterior Horn	Volume	415.7 ± 43.26	0.256	393.5 ± 108.3	0.3946	498.6 ± 59.35
Anterior Horn	Count	2.250 ± 0.1220	0.5494	2.100 ± 0.2769	0.4309	2.375 ± 0.1724
Posterior Horn	Volume	1405 ± 314.8	0.0011	1311 ± 725.9	0.0132	253.6 ± 56.20
Posterior Horn	Count	1.528 ± 0.1290	0.0037	1.200 ± 0.3266	0.3999	0.9063 ± 0.1641
Body of Lateral	Volume	1802 ± 384.3	0.0005	2578 ± 1538	0.0096	290.1 ± 55.70
Ventricles
Body of Lateral	Count	2.944 ± 0.2899	0.0019	2.000 ± 0.5774	0.5351	1.625 ± 0.2831
Ventricles
Temporal Horn	Volume	49.17 ± 21.29	0.3043	543.7 ± 543.7	0.086	21.15 ± 15.79
Temporal Horn	Count	0.2500 ± 0.09237	0.4207	0.1000 ± 0.1000	0.6666	0.1563 ± 0.06521

^*PVL = Periventricular Lesions

^**T2WI and FLAIR images were analyzed using JIM version 5.0 software to measure PVL volume. Unpaired t-test was used for statistical analysis and calculation of p-value.

^***P-values in bold are considered statistically significant.