TABLE 3.
Ambulatory blood pressure control rates (<130/80 mmHg), change in 24-h mean ambulatory blood pressure, mean office (sitting) blood pressure, daytime mean ambulatory blood pressure, night-time mean ambulatory blood pressure, daytime/night-time mean ambulatory blood pressure ratio, early morning mean ambulatory blood pressure, morning surge mean ambulatory blood pressure, mean ambulatory blood pressure variability, poor responders and responders mean ambulatory blood pressure and nondipper and dipper night-time mean ambulatory blood pressure from baseline at Weeks 12 and 26 (LOCF)
| Value (mean ± SD) | Valsartan a.m. | Valsartan p.m. | Lisinopril | Valsartan a.m. | Valsartan p.m. | Lisinopril |
| Week 12 | Week 26 (LOCF) | |||||
| No. of patients | 316 | 323 | 314 | 327 | 338 | 326 |
| Ambulatory BP control (%) | 36.7 | 35.0 | 39.5 | 40.7 | 39.7 | 43.3 |
| 24-h maSBP (mmHg) | −10.6 ± 11.5 | −9.8 ± 11.2 | −10.7 ± 11.3 | −13.3 ± 12.3 | −12.3 ± 12.5 | −13.7 ± 11.6 |
| 24-h maDBP (mmHg) | −6.2 ± 7.0 | −5.6 ± 6.8 | −6.7 ± 7.4 | −7.4 ± 7.4 | −7.3 ± 7.9 | −7.9 ± 7.7 |
| Office msSBP (mmHg) | −14.7 ± 15.2 | −15.3 ± 13.5 | −15.1 ± 14.1 | −16.2 ± 15.1 | −16.7 ± 14.5 | −16.0 ± 15.5 |
| Office msDBP (mmHg) | −7.0 ± 8.6 | −7.8 ± 8.1 | −7.5 ± 8.6 | −7.8 ± 9.1 | −8.4 ± 9.0 | −8.3 ± 9.2 |
| Daytime maSBP (mmHg) | −10.7 ± 12.4 | −9.5 ± 12.5 | −10.5 ± 12.6 | −13.3 ± 13.1 | −12.4 ± 13.8 | −13.5 ± 13.1 |
| Daytime maDBP (mmHg) | −6.2 ± 7.6 | −5.4 ± 8.1 | −6.6 ± 8.6 | −7.6 ± 8.3 | −7.4 ± 9.0 | −7.9 ± 8.7 |
| Night-time maSBP (mmHg) | −11.2 ± 14.2 | −10.3 ± 13.5 | −11.5 ± 13.1 | −13.7 ± 15.6 | −12.7 ± 14.1 | −14.0 ± 13.2 |
| Night-time maDBP (mmHg) | −6.5 ± 9.1 | −5.9 ± 8.1 | −7.1 ± 8.4 | −7.4 ± 9.2 | −7.6 ± 9.0 | −8.0 ± 8.7 |
| Daytime/night-time maSBP ratio | 0.01 ± 0.09 | 0.02 ± 0.09 | 0.02 ± 0.09 | 0.01 ± 0.1 | 0.01 ± 0.09 | 0.02 ± 0.1 |
| Daytime/night-time maDBP ratio | 0.01 ± 0.11 | 0.02 ± 0.12 | 0.02 ± 0.12 | 0.01 ± 0.12 | 0.02 ± 0.12 | 0.02 ± 0.12 |
| Early morning (600–800 h) maSBP (mmHg) | −11.5 ± 16.6 | −10.4 ± 14.8 | −10.3 ± 16.1 | −14.2 ± 16.8 | −12.1 ± 16.4 | −13.6 ± 16.4 |
| Early morning (600–800 h) maDBP (mmHg) | −6.5 ± 10.8 | −5.8 ± 9.4 | −6.7 ± 11.2 | −7.5 ± 11.2 | −7.3 ± 11.2 | −7.8 ± 11.5 |
| Morning surge maSBP (mmHg) | −0.9 ± 15.3 | −0.8 ± 15.2 | 0.6 ± 15.2 | −0.9 ± 15.8 | −0.3 ± 14.8 | −0.5 ± 16.4 |
| Morning surge maDBP (mmHg) | −0.6 ± 11.2 | −0.5 ± 10.8 | −0.1 ± 11.4 | −0.3 ± 11.2 | −0.6 ± 11.0 | −0.2 ± 11.6 |
| maSBP variability (mmHg) | −0.1 ±± 4.1 | 0.0 ± 4.2 | 0.2 ± 4.3 | 0.2 ± 4.7 | −0.2 ± 4.1 | 0.0 ± 4.5 |
| maDBP variability (mmHg) | 0.0 ± 2.7 | 0.0 ± 3.1 | 0.0 ± 3.1 | 0.1 ± 3.2 | −0.2 ± 3.0 | −0.1 ± 3.2 |
| Poor responders: maSBP | −7.0 ± 12.1 | −5.2 ± 10.3 | −5.0 ± 10.5 | −13.7 ± 13.9 | −14.0 ± 12.6 | −14.8 ± 13.4 |
| Responders: maSBP | −13.8 ± 10.1 | −13.7 ± 10.7 | −14.7 ± 9.4 | −13.4 ± 10.9 | −11.3 ± 12.4 | −13.2 ± 10.0 |
| Nondipper: night-time maSBP | −12.8 ± 14.3 | −12.0 ± 13.9 | −13.7 ± 13.4 | −16.8 ± 15.6 | −14.9 ± 14.1 | −16.4 ± 13.3 |
| Dipper: night-time maSBP | −8.4 ± 11.7 | −8.5 ± 11.8 | −9.1 ± 11.3 | −9.4 ± 12.9 | −10.1 ± 13.8 | −11.9 ± 12.5 |
BP, blood pressure; maDBP, mean ambulatory DBP; maSBP, mean ambulatory SBP; msDBP, mean sitting DBP; msSBP, mean sitting SBP.